B cells cultured with anti-IgM, BSF-p1, and B15-TRF will differentiate into high rate IgM-synthesizing cells in the presence of supernatants from EL-4 cells that have been induced with phorbol myristate acetate. These supernatants contain two molecular species (EL-TRFs) that have differentiative activity. One co-migrates with interleukin 2 (IL-2) and its activity is blocked by antibody to the I...

In order to deduce the predominant haplotypes in Japanese narcoleptics, we have studied a total of 111 Japanese patients with narcolepsy and six multiple-case families for HLA class I and class II antigens, and for class III HLA-linked complement markers. In Japanese narcoleptics, the most frequent haplotypes were B35-DR2, B15-DR2, and B51-DR2. These haplotypes were rare in normal Japanese popu...

OBJECTIVE We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. We aimed to study the selection, activation, and development of the diabetogenic capacity of these insulin-reactive T-cells. RESEARCH DESIGN AND M...

Insulin-reactive CD8 T cells are amongst the earliest islet-infiltrating CD8 T cells in NOD mice. Cloned insulin B15-23-reactive cells (designated G9C8), restricted by H-2K(d), are highly diabetogenic. We used altered peptide ligands (APL) substituted at TCR contact sites, positions (p)6 and 8, to investigate G9C8 T cell function and correlated this with structure. Cytotoxicity and IFN-gamma pr...

Plymouth Marine Laboratory, Prospect Place, Plymouth, PL1 3DH, UK. School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK, Department of Molecular Biology, Umeå University, S-901 87 Umeå, Sweden, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK and Institute of Infections and Immunity, University of Nottingham, Queen’s Medical Centre, Nottin...

Huan Yang,1, 2 Larry R. Price,3 Nicolás D. Smith,3 Haixing Miao,4 Yanbei Chen,5 and Rana X. Adhikari3 Perimeter Institute for Theoretical Physics, Waterloo, Ontario N2L2Y5, Canada Institute for Quantum Computing, University of Waterloo, Waterloo, Ontario N2L3G1, Canada∗ Division of Physics, Math, and Astronomy, California Institute of Technology, Pasadena, CA 91125, USA School of Physics and As...

D. J. Thouless, M. R. Geller, W. F. Vinen, J.-Y. Fortin, and S. W. Rhee Department of Physics, University of Washington, Box 351560, Seattle, Washington 98195 Department of Physics and Astronomy, University of Georgia, Athens, Georgia 30602 School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT, England CNRS Laboratoire de Physique Théorique, Université Louis Pasteur, 670...

a Burns and Allen Research Institute, Division of Endocrinology, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA b Division of Immunity and Infection, Institute of Biomedical Research, The University of Birmingham Medical School, Birmingham B15 2TT, UK c Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medi...

Xiaoqing Shi , Philip Prewett , Ejaz Huq , Darren M Bagnall , Alex P G Robinson, Stuart A Boden , a Electronics and Computer Science, University of Southampton, Southampton, SO16 1BJ, UK b Oxford Scientific Consultants Ltd., 67 High Street, Dorchester, Oxfordshire, OX10 7HN, UK c Faculty of Engineering, The University of New South Wales 3, Sydney, NSW 2052, Australia d School of Chemical Engine...

University of Birmingham Centre for Cardiovascular Sciences, Institute for Biomedical Research, 1st Floor, Birmingham B15 2TT, UK; Department of Cardiovascular Medicine, University of Münster, Münster, Germany; Department of Medicine, University at Buffalo, Buffalo, NY, USA; Arrhythmia Service, University Hospital, University of Western Ontario, London, ON, Canada; Libin Cardiovascular Institut...