Logging experiments with the laboratory-information management system ISPyB (Information System for Protein crystallography Beamlines) enhances the automation of small-angle X-ray scattering of biological macromolecules in solution (BioSAXS) experiments. The ISPyB interface provides immediate user-oriented online feedback and enables data cross-checking and downstream analysis. To optimize data...

We have studied the effects of brefeldin A (BFA) on endocytosis and intracellular traffic in polarized MDCK cells by using the galactose-binding protein toxin ricin as a membrane marker and HRP as a marker of fluid phase transport. We found that BFA treatment rapidly increased apical endocytosis of both ricin and HRP, whereas basolateral endocytosis was unaffected, as was endocytosis of HRP in ...

In 1893 Andreas Heinrich Voigt published “Zahl und Mass in der Ökonomik” (“Number and Measurement in Economics,” Zeitschrift für die gesamte Staatswissenschaft), in which he argued that utility admits only an ordinal characterization. This paper compares Voigt’s views on ordinalism with those of his contemporaries, and also discusses Voigt’s impact on later economic thought. F.Y. Edgeworth soon...

Various modern decision theories seek to capture the intuition behind Keynes‟s conception of evidential weight. Keynes was nevertheless hesitant about the practical relevance of weight in the process of rational decision making because of the „stopping problem‟ of finding a rational principle to decide where to stop the process of acquiring information in forming a probability judgment before m...

Two hundred and eighty nine unrelated Marathas residing in Mumbai, Maharastra, (Western India) were studied for HLA A, B, C and DR locus antigen profiles. The HLA antigen maximum likelihood gene frequencies of HLA A1, A2, A9 (24), A11, A19 (33), B5, B7, B35, B40 (61), Cw3, Cw6, DR2, DR5, DR7, DQ1 and DQ2 were increased while that of HLA A3, A10 (26), A36, B8, B13, B16 (38), B18, B21, B22 (55), ...

Recently two groups have listed all sets of weights k = (k1, . . . , k5) such that the weighted projective space IP4 k admits a transverse Calabi–Yau hypersurface. It was noticed that the corresponding Calabi–Yau manifolds do not form a mirror symmetric set since some 850 of the 7555 manifolds have Hodge numbers (b11, b21) whose mirrors do not occur in the list. By means of Batyrev’s constructi...

A G-design of order n is a pair (P, B) where P is the vertex set of the complete graph Kn and B is an edge-disjoint decomposition of Kn into isomorphic copies of the simple graph G. Following terminology, we call these copies "blocks". Given a particular the intersection problem asks for which k is it possible to find two (P, Bl) and (P, B 2) of order n, with IBI n B21 = k, that is, with k comm...

BACKGROUND Clinical and preclinical observations indicate that Lactobacillus plantarum has anti-inflammatory activity and may regulate the immune responses of its hosts when ingested. Recently, modification of teichoic acids (TAs) produced by L. plantarum was reported as a key to regulating the systemic immune response in mice. However, data linking TA-related genetic determinants and the immun...

OBJECTIVE To evaluate urinary 8-hydroxydeoxyguanosine (8-OHdG) as a marker for the progression of diabetic macroangiopathic complications. RESEARCH DESIGN AND METHODS The content of urinary 8-OHdG, common carotid intima-media thickness (IMT), the coronary heart disease (CHD) risk score, the severity of diabetic retinopathy, and urinary albumin excretion were examined in 96 patients with type ...

The Harvard School began with the early Mason/Bain research about the performance of the firms to get market power. This proposal opened a different field of the neoclassical economic theory valid since Alfred Marshall, whereas the Chicago scholars continued with the traditional paradigm. Nowadays the three main issues of discussion between these two schools of economic thought are the same as ...