The global spread of bacterial resistance to drugs used in therapy requires new potent and safe antimicrobial agents. DNA gyrases represent important targets in drug discovery. Schiff bases, thiazole, and triazole derivatives are considered key scaffolds in medicinal chemistry. Fifteen thiazolyl-triazole Schiff bases were evaluated for their antibacterial activity, measuring the growth inhibiti...

We report high-field magnetotransport measurements on b9-(BEDT-TTF)4@(H3O)M (C2O4)3#Y , where M 5Ga, Cr, and Fe and Y5C5H5N. We observe similar Shubnikov–de Haas oscillations in all compounds, attributable to four quasi-two-dimensional Fermi-surface pockets, the largest of which corresponds to a crosssectional area '8.5% of the Brillouin zone. The cross-sectional areas of the pockets are in agr...

HORTSCIENCE VOL. 41(1) FEBRUARY 2006 annuum L.), pineapple [Ananas comosus (L.) Merrill], potato (Solanum tuberosum L.), spinach, strawberry (Fragaria ×ananassa Duch.), and tomato (Lycopersicum esculentum Mill.). Ascorbic acid is critical in maintaining a healthy immune system, reducing the severity of colds by preventing secondary viral or bacterial infections, protecting against damage by red...

Beslenme, fiziksel durumla ilişkili olduğu kadar beynin gelişimi ve işleyişiyle de ilişkilidir. Merkezi sinir sistemi üzerine koruyucu etkileri olan besinler arasında proteinler, karbonhidratlar, çoklu doymamış yağ asitleri, vitaminler (C, E, D, B12, B9, B6 B1 vitaminleri) mineraller (selenyum, çinko, magnezyum, sodyum, demir, bakır, iyot) yer almaktadır. Diyette antioksidan besinlerin varlığı,...

BACKGROUND The ras family of proto-oncogenes encodes for small GTPases that play critical roles in cell-cycle progression and cellular transformation. ERK1/2 MAP kinases are major ras effectors. Tumors in chemically treated mouse skin contain mutations in the Ha-ras proto- oncogene. Amplification and mutation of Ha-ras has been shown to correlate with malignant progression of these tumors. Cell...