BACKGROUND Ketamine is an anesthetic drug. Subanesthetic doses of ketamine have been shown to reduce interleukin-6 concentrations after surgery and to reduce mortality and the production of tumor necrosis factor alpha and interleukin 6 in septic animals. Similarly, adenosine was shown to reduce tumor necrosis factor alpha and mortality of septic animals. The aim of this study was to determine w...

The rhizosphere competence of 15 in vitro antagonists of Rhizoctonia solani was determined 4 weeks after sowing inoculated lettuce seeds into nonsterile soil. Based on the colonization ability determined by selective plating, eight strains were selected for growth chamber experiments to determine their efficacy in controlling bottom rot caused by R. solani on lettuce. Although in the first expe...

Abstract Background Apple decline diseases, responsible for seedlings root and collar rot in nurseries, are an important disease. Different fungal bacterial antagonists were evaluated to control Pythium ultimum associated with this serious disease using vitro vivo greenhouse assays. Results The test of ten Aspergillus spp. Trichoderma harzianum isolates showed their efficacy reduce the radial g...

The interactions between bacterial pathogens and their eukaryotic hosts are vital in determining the outcome of infections. Bacterial pathogens employ molecular sensors to detect and facilitate adaptation to changes in their niche. The sensing of these extracellular signals enables the pathogen to navigate within mammalian hosts. Intercellular bacterial communication is facilitated by the produ...

Micro-organisms isolated from composts were assayed in vitro for inhibition of mycelial growth and conidium germination of Fusarium culmorum. Eleven bacterial isolates inhibited mycelial growth, and of these seven also inhibited germination of conidia. However, inhibition of mycelial growth was only reproducible for three bacteria. Five fungal isolates were found to have antagonistic effects on...

Anti bacterial activities of several „non-antibiotic drugs‟ used in treatment of a variety of noninfectious human diseases have been observed. Such an effect has been noticed for barbiturates, beta-adrenergic receptor antagonists, diuretic drugs, H1 antihistamines, mucolytic agents, non-steroidal anti-inflammatory drugs, proton pump inhibitors and psychotherapeutic drugs. A synergic or antagoni...

OBJECTIVE to test whether omeprazole taken for longer than 1 month causes an increase in the rate of small bowel bacterial overgrowth in elderly subjects. SUBJECTS 44 elderly people, 22 taking omeprazole, 22 not taking omeprazole or H2 receptor antagonists. MAIN OUTCOME MEASURES rate of positive glucose-hydrogen breath tests; anthropometric measures and blood tests reflecting malabsorption....

Quorum sensing, a process of bacterial cell-cell communication, relies on production, detection, and response to autoinducer signaling molecules. LuxN, a nine-transmembrane domain protein from Vibrio harveyi, is the founding example of membrane-bound receptors for acyl-homoserine lactone (AHL) autoinducers. We used mutagenesis and suppressor analyses to identify the AHL-binding domain of LuxN a...

There have been intensive efforts to find small molecule antagonists for bacterial quorum sensing (QS) mediated by the "universal" QS autoinducer, AI-2. Previous work has shown that linear and branched acyl analogues of AI-2 can selectively modulate AI-2 signaling in bacteria. Additionally, LsrK-dependent phosphorylated analogues have been implicated as the active inhibitory form against AI-2 s...