About 20 % of neonates develop sepsis and among them approximately 1% die due to sepsis-related causes. Bacterial pathogens are the commonest cause neonatal which is either early-onset (<72 hours age) or late-onset (>72 hours). Little known about epidemiology antimicrobial susceptibility pattern causing bacterial in Nepal. A prospective study was carried out suspected have admitted Tribhu...

Sepsis remains a major global healthcare problem, indicate as most frequently cause of morbidity and mortality worldwide. The last consensus sepsis in 2016 defined life threatening organ dysfunction caused by dysregulated host response to infection. Dysfunction organs can be represented Sequential [Sepsis-Related] Organ Failure Assessment (SOFA) score. Score2 points or more consequent the Nowad...

materials and methods the level of plasma il-6 and blood culture were checked in all the term neonates suspicious to sepsis admitted to the neonatal intensive care unit of shahid beheshti hospital of kashan during 2010-2011. positive blood culture was considered as definite sepsis and negative blood culture as suspicious sepsis. then, the level of il-6 was compared with the state of blood cultu...

Abstract Sepsis is a life-threatening condition caused by the extreme release of inflammatory mediators into blood in response to infection (e.g., bacterial infection, COVID-19), resulting dysfunction multiple organs. Currently, there no direct treatment for sepsis. Here we report an abiotic hydrogel nanoparticle (HNP) as potential therapeutic agent late-stage The HNP captures and neutralizes a...

abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...

The route of infection can profoundly affect both the progression and outcome of disease. We investigated differences in Drosophila melanogaster defense against infection after bacterial inoculation into two sites--the abdomen and the thorax. Thorax inoculation results in increased bacterial proliferation and causes high mortality within the first few days of infection. In contrast, abdomen ino...

Background. Infant mortality in the United States has continued to decline in recent years, but changes in sepsis-associated deaths among infants have not been evaluated previously. Methods. Data from US death records were analyzed for the period 1979 through 1994 to assess trends in sepsis-associated deaths among newborns and older infants. Results. Annual neonatal mortality associated with se...

BACKGROUND Statins have anti-inflammatory properties that are independent of their lipid-lowering abilities. We hypothesized that statin therapy before the onset of an acute bacterial infection may have a protective effect against severe sepsis. The aim of this study was to determine whether patients treated with statins develop severe sepsis less frequently. METHODS AND RESULTS In this prosp...

BACKGROUND Sepsis is a global healthcare problem, characterized by whole body inflammation in response to microbial infection, which leads to organ dysfunction. It is becoming a frequent complication in hospitalized patients. Early and differential diagnosis of sepsis is needed critically to avoid unnecessary usage of antimicrobial agents and for proper antibiotic treatments through the screeni...