In the field of medicinal chemistry, Quinazolinone is a heterocyclic compound having unique place which has medicinal uses as Anticancer, antihypertensive, antihyperlipidemic, antitubercular, CNS depressant, antioxidant, analgesic, antibacterial, anti-inflammatory and antimalarial activity. Quinazolinone based drugs have broadened scope in the field of medicine and Research. Some quinazolinone ...

The information available to any organism is encoded in a four nucleotide, two base pair genetic code. Since its earliest days, the field of synthetic biology has endeavored to impart organisms with novel attributes and functions, and perhaps the most fundamental approach to this goal is the creation of a fifth and sixth nucleotide that pair to form a third, unnatural base pair (UBP) and thus a...

A Matched Molecular Pair (MMP) is a pair of compounds which differ only by a well-defined structural transformation [1,2]. Together with large-scale mining of activity or physicochemical data, matched molecular pair analysis (MMPA) has the potential to aid the design of molecules with improved properties by highlighting favourable transformations. Here we greatly enhance the performance of MMPA...

An important question in organic chemistry is how does a chemist synthesize chemicals in the most efficient way beginning with chemicals readily available. These problems are known as synthesis problems. Currently, methods based on databases (Chen, 2006) and methods related to quantum mechanics (Jorgensen, 1998) are used frequently to solve this problem. When solving synthesis problems by hand,...

We present a novel application of best N-term approximation theory in the framework of electronic structure calculations. The paper focus on the description of electron correlations within a Jastrow-type ansatz for the wavefunction. As a starting point we discuss certain natural assumptions on the asymptotic behaviour of two-particle correlation functions F(2) near electron-electron and electro...

Practicum is critical for students to develop their abilities and comprehension of the subject being studied. The lack a laboratory assistant, as well limited instruments practicum materials, are primary reasons why activities not performed in schools. Therefore, use materials which available everyday life can be an alternative keep carrying out. This study aimed simple chemistry video on green...

fatemeh karimi tabar was born in asadabad/hamedan (iran) in 1986. she completed her b.sc. in chemistry in 2008 from bu-ali sina university, hamedan, iran. she was graduated from m.sc. degree in organic chemistry from shiraz university 2010, shiraz, iran. she is currently organic chemistry ph.d student under the supervision of prof. m.a. zolfigol and prof. a. khazaei in department of chemistry a...

Aprotic sodium-O2 batteries require the reversible formation/dissolution of sodium superoxide (NaO2 ) on cycling. Poor cycle life has been associated with parasitic chemistry caused by the reactivity of electrolyte and electrode with NaO2 , a strong nucleophile and base. Its reactivity can, however, not consistently explain the side reactions and irreversibility. Herein we show that singlet oxy...

Abstract The extent of a chemical reaction has received little attention in the early stages of Chemistry teaching, despite allowing a general way to work with chemical reactions and equilibria. In this article, the concepts of extent of reaction and extent of reaction balances are revised and several applications to study the change in the concentrations of the species involved in chemical rea...

DNA charge transport chemistry offers a means of long-range, rapid redox signaling. We demonstrate that the [4Fe4S] cluster in human DNA primase can make use of this chemistry to coordinate the first steps of DNA synthesis. Using DNA electrochemistry, we found that a change in oxidation state of the [4Fe4S] cluster acts as a switch for DNA binding. Single-atom mutations that inhibit this charge...