cate that Shh signalling controls Laminin gene expression, a critical step in the formation of the myotomal basement membrane, and that Laminin-111 has specific and essential role in myotomal basement membrane assembly. Together, our data reveal a novel role for Shh signalling in the control of basement membrane assembly and provide a framework for understanding the complex interactions between...

Spontaneously occurring anterior corneal opacities were present in related, juvenile American Dutch belted rabbits. Slit lamp biomicroscopy revealed focal opacities of epithelium, basement membrane, and subepithelial corneal stroma. Lesions were characterized histologically by thin and disorganized surface epithelium, thickened and intensely staining epithelial basement membrane, fimbriated and...

Ferritin-conjugated antibody has been used to identify by electron microscopy the sites at which nephrotoxic globulins localize in rat kidney during acute experimental glomerulonephritis. Antibody was concentrated in the glomerular basement membrane and in basement membrane-like material contained in distended cisternae of the endoplasmic reticulum. These data confirm and amplify, at the ultras...

Glomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glomerular basement membrane. The glomerular basement membranes of nephritic animals were observed to develop subepithelial extensions, "spikes." Although normally Type IV collagen is found throughout the full thickness of basement membranes, the "spikes" reacted with antibodies to laminin but not wi...

introduction & objective: the brain choroids plexus (bcp) plays an important role in the cerebrospinal fluid (csf) production, but its characterization is still incomplete. collagen type iv, is one of the most important proteins of basement membrane (bm) and extracellular matrix (ecm) of bcp. in the present study we investigated the differential period of type iv collagen in basement membrane o...

cate that Shh signalling controls Laminin gene expression, a critical step in the formation of the myotomal basement membrane, and that Laminin-111 has specific and essential role in myotomal basement membrane assembly. Together, our data reveal a novel role for Shh signalling in the control of basement membrane assembly and provide a framework for understanding the complex interactions between...