We carried out the first simulation on multi-stage continuous high cell density culture (MSC-HCDC) to show that the MSC-HCDC can achieve batch/fed-batch product titer with much higher productivity to the fed-batch productivity using published fermentation kinetics of lactic acid, penicillin and ethanol. The system under consideration consists of n-serially connected continuous stirred-tank reac...

Suppose that we have one run of n observations of a stochastic process by means of computer simulation and would like to construct a condifence interval for the steady-state mean of the process. Seeking for independent observations, so that the classical statistical methods could be applied, we can divide the n observations into k batches of length m (n= k.m) or alternatively, transform the cor...

front of the batch processor, where they wait to be processed. The batch processor has a finite capacity Q, and the processing time is independent of the number of jobs loaded into the batch processor. In certain manufacturing systems (including semiconductor wafer fabrication), a processing time window exists from the time the job exits the feeder processor till the time it enters the batch pr...

Increasing numbers of filter materials have been proposed as suitable media for P removal in on-site wastewater treatment systems. The phosphorus sorption capacity (PSC) of the material can be estimated in batch experiments and is commonly used as the criterion for material selection. However, there is no standard procedure and batch experimental parameters are arbitrarily established, thus lea...

A dynamic model of glucose overflow metabolism in batch and fed-batch cultivations of Escherichia coli W3110 under fully aerobic conditions is presented. Simulation based on the model describes cell growth, respiration, and acetate formation as well as acetate reconsumption during batch cultures, the transition of batch to fed-batch culture, and fed-batch cultures. E. coli excreted acetate only...

OBJECTIVE To develop a competency based discriminatory assessment method for physiology practical examination. METHOD Results from 1st professional M.B.B.S. Part I and II of three batches were taken and students performance in traditional and objective structured practical examination (OSPE) were compared. The course objective for practical examination of all three batches were same. However,...

This paper presents a novel distributed batch Gaussian process upper confidence bound (DB-GP-UCB) algorithm for performing batch Bayesian optimization (BO) of highly complex, costly-to-evaluate black-box objective functions. In contrast to existing batch BO algorithms, DBGP-UCB can jointly optimize a batch of inputs (as opposed to selecting the inputs of a batch one at a time) while still prese...

Manufacturers using traditional process control charts to monitor their sheet metal stamping processes often encounter out-of-control signals indicating that the process mean has changed. Unfortunately, a sheet metal stamping process does not have the necessary adjustability in its process variable input settings to allow adjusting the mean response in an out-of-control condition, hence the sig...

Many previous studies focused on the removal capability for contaminants when the algae grown in an unexposed, unpolluted environment and ignored whether the feedback of algae to the toxic stress influenced the removal capability in a subsequent treatment batch. The present research investigated and compared algal feedback and removal efficiency in a sequencing batch reactor algae process (SBAR...