microparticles offer various significant advantages as drug delivery systems, including: (i) an effective protection of the encapsulated active agent against (e.g. enzymatic) degradation, (ii) the possibility to accurately control the release rate of the incorporated drug over periods of hours to months, (iii) an easy administration (compared to alternative parenteral controlled release dosage ...

Glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. Therefore, development of an efficient strategy for treatment of glioma is worthy. The aim of the current study was to develop a SRL peptide-coated dendrimer as a novel dual gene delivery system for targeting the LRP receptor, an up-regulated gene in both BBB and glioma cells. To perf...

Data split into batches is very common in real-world applications. In speech recognition and handwriting identification, the batches are different people. In areas like oil spill detection and train wheel failure prediction, the batches are the particular circumstances when the readings were recorded. The recent research has proved that it is important to respect the batch structure when learni...

We recently introduced an efficient technique for out-of-core rendering and management of large textured landscapes. The technique, called Batched Dynamic Adaptive Meshes (BDAM), is based on a paired tree structure: a tiled quadtree for texture data and a pair of bintrees of small triangular patches for the geometry. These small patches are TINs that are constructed and optimized off-line with ...

In this work we present new kernels for the generation and application of block-Jacobi preconditioners that accelerate the iterative solution of sparse linear systems on graphics processing units (GPUs). Our approach departs from the conventional LU factorization and decomposes the diagonal blocks of the matrix using the Gauss-Huard method. When enhanced with column pivoting, this method is as ...

Glioma, as a primary tumor of central nervous system, is the main cause of death in patients with brain cancer. Therefore, development of an efficient strategy for treatment of glioma is worthy. The aim of the current study was to develop a SRL peptide-coated dendrimer as a novel dual gene delivery system for targeting the LRP receptor, an up-regulated gene in both BBB and glioma cells. To perf...