Disseminated mycobacterial infection after Bacille Calmette-Guérin (BCG) vaccination is a rare disorder, usually presenting with fever, weight loss, anemia, lymphadenopathy and hepatosplenomegaly. We report a case of disseminated BCG infection in a 28-month-old girl with prolonged fever and abdominal mass due to retroperitoneal abscess. Appropriate therapy resulted in a good response. This is t...

For some years, since Fernandez (1) showed that reactivity to lepromin can be induced by BCG vaccination, a fact soon confirmed by other workers, and especially since an intensive study of the matter was begun in Sao Paulo (3-11), much interest has been taken in the possibility that BCG vaccination may be of signal value in the prophylaxis. One of the questions frequently asked is whether or no...

Background: Tuberculosis (TB) is a re-emerging problem, especially in the larger cities of Western Europe. Selective neonatal BCG vaccination is recommended for infants at risk of TB in the UK. Neonatal BCG is safe and effective, with an overall protective value of 75%. This study aimed to assess BCG rates among at risk infants in Cardiff and the Vale of Glamorgan, South Wales in the year 2003....

OBJECTIVES To investigate the safety and immunogenicity of a booster BCG vaccination delivered intradermally in healthy, BCG vaccinated subjects and to compare with a previous clinical trial where BCG vaccinated subjects were boosted with a new TB vaccine, MVA85A. DESIGN Phase I open label observational trial, in the UK. Healthy, HIV-negative, BCG vaccinated adults were recruited and vaccinat...

Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols bu...

Previous work with small-animal laboratory models of tuberculosis has shown that vaccination strategies based on heterologous prime-boost protocols using Mycobacterium bovis bacillus Calmette-Guérin (BCG) to prime and modified vaccinia virus Ankara strain (MVA85A) or recombinant attenuated adenoviruses (Ad85A) expressing the mycobacterial antigen Ag85A to boost may increase the protective effic...

A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which include genetically modified mycobacteria, mycobacterial antigens delivered by viral vectors, or mycobacterial antigens in adjuvant. Some of these vaccines aim to replace the existing BCG vaccine but others will be given as a boosting vaccine following BCG vaccination given soon after birth. It is clear ...

The bacilli Calmette-Guérin (BCG) vaccine is administered to all newborns in countries where tuberculosis is endemic. Immunocompromised hosts, namely patients with human immunodeficiency virus infection or primary immunodeficiencies, are especially prone to serious complications from this vaccine. We report three cases of BCG disease in children with primary immunodeficiencies: one with a parti...

conclusions post immunization lv is a rare complication of the bcg vaccine and should be considered by any physician. lupus vulgaris is a paucibacillary form of tb. therefore, acid fast bacilli are not detected in most cases. the pcr is a useful method for confirmation of the diagnosis of lv. introduction lupus vulgaris (lv) is one type of cutaneous tuberculosis (tb) but a rare complication of ...

a field trial was canied outon60 volunteers selected in yazd province, central iran, with a vaccine containing killed promastigotes of l. major prepared by the razi institute, hessarak. during these phase i studies which lasted for more than two years, we examined acceptable doses of the vaccine alone or mixed with bcg. the results so far indicate that 50 to 1000 µg of the vaccine alone can be ...