The BEACH domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. However, it does not share any sequence homology with other proteins. Here we report the crystal structure at 2.9 A resolution of the BEACH domain of human neurobeachin. It shows that the BEACH domain has a new and un...

I summarize key aspects of the quest for physics beyond the Standard Model in flavour physics as discussed at the BEACH 2014 conference in Birmingham.

Forced by tides and waves, large volumes of seawater are flushed through the beach daily. Organic material and nutrients in seawater are remineralized and cycled as they pass through the beach. Microorganisms are responsible for most of the biogeochemical cycling in the beach; however, few studies have characterized their diversity in intertidal sands, and little work has characterized the exte...

BACKGROUND Beach chair positioning during general anesthesia is associated with cerebral oxygen desaturation. Changes in cerebral oxygenation resulting from the interaction of inspired oxygen fraction (FIO2), end-tidal carbon dioxide (PETCO2), and anesthetic choice have not been fully evaluated in anesthetized patients in the beach chair position. METHODS This is a prospective interventional ...

New approaches should be considered as the US Environmental Protection Agency (EPA) moves rapidly to develop new beach monitoring guidelines by the end of 2012, as these guidelines serve as the basis by which states and territories with coasts along the oceans and Great Lakes can then develop and implement monitoring programs for recreational waters. We describe and illustrate one possible appr...

Numerical modelling of beach morphodynamics is generally recognized as a valuable tool for scientists and coastal managers. However, the utility of numerical models is constrained by our ability to establish that the theoretical dynamics match reality. The integrated modules for simulating wave propagation, hydrodynamics and sediment transport in Delft3D, developed by Delft Hydraulics, were app...

Sandy ocean beaches are iconic assets that provide irreplaceable ecosystem services to society. Despite their great socioeconomic importance, beaches as ecosystems are severely under-represented in the literature on climate-change ecology. Here, we redress this imbalance by examining whether beach biota have been observed to respond to recent climate change in ways that are consistent with expe...

In situ abrasion of shingle beach material is a neglected area of study in coastal geomorphology, with reduction in beach volumes normally attributed to longshore and offshore drift. Results from field abrasion experiments conducted on flint shingle beaches on the East Sussex coast, southern England, show that in situ reductions in volume of beach material may be more significant than has been ...

Membrane trafficking to the protein storage vacuole (PSV) is a specialized process in seed plants. However, this trafficking mechanism to PSV is poorly understood. Here, we show that three types of Beige and Chediak-Higashi (BEACH)-domain proteins contribute to both vacuolar protein transport and effector-triggered immunity (ETI). We screened a green fluorescent seed (GFS) library of Arabidopsi...