H. Goldberg-Stern *, O.M. Gonen , M. Sadeh , S. Kivity , A. Shuper , D. Inbar c,d a Epilepsy Center, Schneider Children’s Medical Center of Israel, Petah Tiqwa, Israel Department of Neurology, Schneider Children’s Medical Center of Israel, Petah Tiqwa, Israel Child Developmental Institute, Schneider Children’s Medical Center of Israel, Petah Tiqwa, Israel d Sackler Faculty of Medicine, Tel Aviv...

INTRODUCTION Despite the success of epilepsy surgery, recent reports suggest a decline in surgical numbers. We tested these trends in our cohort to elucidate potential reasons. PATIENTS AND METHODS Presurgical, surgical and postsurgical data of all patients undergoing presurgical evaluation in between 1990 and 2013 were retrospectively analysed. Patients were grouped according to the underlyi...

We assessed language lateralization in 177 healthy 4- to 11-year-old children and adults and atypical asymmetries associated with unilateral epileptic foci in 18 children with benign epilepsy with centrotemporal spikes (BECTS). Dichotic listening results revealed two indices of immature functional asymmetry when the focus was left-sided (BECTS-L). First, children with BECTS-L did not show left ...

Prognosis of epilepsy disorders in childhood is very diverse, ranging from benign with rapid recovery to the most severe forms with major cognitive and motor deterioration. Many of these malignant forms of epilepsy are related to developmental disorders of the brain, such as cortical malformations, which can be precisely characterized by MRI (1). Many of these epilepsies are refractory to pharm...

OBJECTIVE To use transcranial magnetic stimulation (TMS) to investigate the hypothesis that sleep deprivation increases cortical excitability in people with epilepsy. METHODS We performed paired pulse TMS stimulation, using a number of interstimulus intervals (ISIs) on each hemisphere of 30 patients with untreated newly diagnosed epilepsy (15 idiopathic generalized epilepsy [IGE] and 15 focal...

Powerful endogenous inhibitory mechanisms are thought to restrict the spread of epileptic discharges in cortical networks. Similar inhibitory mechanisms also influence physiological processing. We reasoned, therefore, that useful information about the quality of inhibitory restraint in individuals with epilepsy may be gleaned from psychophysical assays of these physiological processes. We deriv...

PURPOSE Febrile seizure, the most common type of pediatric convulsive disorder, is a benign seizure syndrome distinct from epilepsy. However, as epilepsy is also common during childhood, we aimed to identify the prognostic factors that can predict epilepsy in children with febrile seizures. METHODS The study comprised 249 children at the Korea University Ansan Hospital who presented with febr...

Children with epilepsy often have attention deficits, even when epilepsy is idiopathic and benign. The mechanisms underlying attention deficits are still unknown and appear to be different between focal and generalized epilepsy. In this study, an attentional capture paradigm was used to study and compare one aspect of attentional control, the resistance to interference from distractors, in 18 c...

PURPOSE OF REVIEW The aim of this article is to review new epilepsy syndromes, acquire a new understanding of older ones and emphasize the impact of this concept on basic research regarding aetiology and treatment. RECENT FINDINGS In addition to those included in the classification of the International League Against Epilepsy, new epilepsy syndromes comprise febrile seizures plus, benign fami...

10.5 million children worldwide are estimated to have active epilepsy. Over the past 15 years, syndrome-oriented clinical and EEG diagnosis, and better aetiological diagnosis, especially supported by neuroimaging, has helped to clarify the diversity of epilepsy in children, and has improved management. Perinatal and postinfective encephalopathy, cortical dysplasia, and hippocampal sclerosis acc...