Mercurated nucleic acids are converted to the corresponding tritiated, brominated, and iodinated derivatives by treatment with sodium borotritiide, N-bromosuccinimide, and elemental iodine, respectively. All three reactions occur under mild conditions in neutral aqueous solutions. Mercury-halogen conversions are essentially quantitative at both the mono- and polynucleotide levels. Tritiation r...

The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone and 1-indanone derivatives, which have recently been shown to potently inhibit MAO, with selectivity for MAO-B (in preference to the MAO-A isoform). 3-Coumaranones are simi...

In the title compound, C(16)H(12)O(4), the 1-benzofuran-one unit is in a planar conformation [C-C-C-C = 179.69 (12)°]. The conformation around the C=C double bond [1.3370 (17) Å] is Z. In the crystal, the mol-ecules are stabilized by O-H⋯O (running parallel to the bc plane) and C-H⋯O hydrogen bonds.

In the title compound, C(20)H(17)NO(4), the double bond of the acrylonitrile group separating the 1-benzofuran moiety from the 3,4,5-trimeth-oxy-phenyl ring has Z geometry. The 1-benzofuran groups are π-π stacked with inversion-related counterparts such that the furan ring centroid-centroid distance is 3.804 (5) Å. The dihedral angle between the planes of the trimeth-oxy-phenyl ring and the acr...