Endothelin 1 mediates coronary vasoconstriction and endothelial dysfunction via endothelin receptor type A (ET(A)) activation. However, the effects of selective endothelin receptor type B (ET(B)) and combined ET(A+B) receptor blockade on coronary vasomotion are unknown. We measured coronary vascular tone and endothelium-dependent and -independent vasomotor function before and after selective in...

The overall disposition and hepatobiliary transport of BQ-123, an anionic cyclopentapeptide, and three analogs were examined in rats in vivo. Total body clearance (CLtotal) and biliary excretion clearance (CLbile, p) exhibited 4- to 8-fold differences between the compounds, with those for BQ-485 and compound A having the highest and lowest values, respectively. The CLbile, p values of BQ-485, B...

Eight Na-repleted volunteers underwent 3 separate 90-minute infusions of either N(G)-nitro-L-arginine methyl ester (L-NAME) 3.0 mg. kg(-1). min(-1) or endothelin-A receptor (ET-A) blocker BQ-123 (BQ) 0.125 nmol. kg(-1). min(-1) or both. Mean arterial pressure (MAP), glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistances (RVR), and sodium excretion rate (UNaV) were ...

Binding and functional studies were conducted to elucidate the receptor subtypes mediating contractions of human bronchus induced by endothelin (ET) receptor ligands. Binding experiments in human bronchial smooth muscle membrane preparations revealed the presence of ETA and ETB receptors in the ratio of approximately 40:60. In the presence of the combination of 1 microM BQ-123 (ETA receptor ant...

In concern of resource sustainability and environmental friendliness, organic electrode materials for rechargeable batteries have attracted increasing attentions in recent years. However, for many researchers, the primary impression on organic cathode materials is the poor cycling stability and low energy density, mainly due to the unfavorable dissolution and low redox potential, respectively. ...

Bq−Bq mixing with q = d or q = s is governed byM −iΓ/2 with the hermitian 2×2 matrices M q and Γ. The (1, 2) element of M q − iΓ/2 induces Bq → Bq transitions. The mass matrix element M q 12 stems from the dispersive part of the box diagram in Fig. 1, which is obtained from the full diagram by replacing the loop integral with its real part. The decay matrix element Γq12 is calculated from the a...

Under secondary metabolic conditions, the white-rot basidiomycete Phanerochaete chrysosporium degraded 2,7-dichlorodibenzo-p-dioxin (I). The pathway for the degradation of I was elucidated by the characterization of fungal metabolites and oxidation products generated by lignin peroxidase (LiP), manganese peroxidase (MnP), and crude intracellular cell-free extracts. The multistep pathway involve...

Here we present the first report of a carbon-γ-Fe₂O₃ nanoparticle composite of mesoporous carbon, bearing COOH- and phenolic OH- functional groups on its surface, a remarkable and magnetically separable adsorbent, for the radioactive material emitted by the Fukushima Daiichi nuclear power plant accident. Contaminated water and soil at a level of 1,739 Bq kg(-1) ((134)Cs and (137)Cs at 509 Bq kg...

Based on past studies of an experimental model of severe intrauterine pulmonary hypertension, we hypothesized that endothelin-1 (ET-1) contributes to high pulmonary vascular resistance (PVR), hypertensive lung structural changes, and right ventricular hypertrophy (RVH) caused by prolonged closure of the ductus arteriosus. To test this hypothesis, we studied the effects of BQ 123, a selective ET...

BACKGROUND Endothelin (ET) is implicated in the pathophysiology of chronic renal failure (CRF). We therefore studied the systemic and renal hemodynamic effects of ET receptor antagonists in CRF and examined differences between selective ETA, selective ETB, and combined ETA/B receptor blockade. METHODS AND RESULTS We conducted a randomized, placebo-controlled, double-blind, 4-way crossover stu...