Multifunctional metal chelators that can modulate the amyloid β (Aβ) peptide aggregation and its interaction with metal ions such as copper and zinc hold considerable promise as therapeutic agents for Alzheimer's disease (AD). However, specific rather than systemic metal chelation by these compounds is needed in order to limit any side effects. Reported herein are two novel small bifunctional c...

The feasibility of ozonation process for 2-mercaptobenzothiazole (2-MBT) removal follows from results of ozonation of the model wastewater. Total removal of 2-MBT was observed after 20 minutes of ozonation. Very good reproducibility of repeated ozonation trials including sampling and analysis was observed. However, the majority of dissolved organic carbon (DOC) and chemical oxygen demand (COD) ...

This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2 SiMe3 )3 , GaR3 ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as...

A highly practical procedure for preparing benzoxazole-2-ones, benzothiazole-2-ones and its 2-thione derivatives using ethylchloroformate and carbon disulfide and the corresponding aminophenols and aminothiophenols as the starting materials in one-pot protocol is presented. The yields vary from good to excellent, the conditions are mild, and the use of toxic and harmful chemicals is avoided. An...