نتایج جستجو برای: binding energetics

تعداد نتایج: 426903  

Journal: :Proteins 2009
Gerhard Meissner Daniel A Pasek Naohiro Yamaguchi Srinivas Ramachandran Nikolay V Dokholyan Ashutosh Tripathy

The skeletal muscle (RyR1) and cardiac muscle (RyR2) ryanodine receptor calcium release channels contain a single, conserved calmodulin (CaM) binding domain, yet are differentially regulated by CaM. Here, we report that high-affinity [(35)S]CaM binding to RyR1 is driven by favorable enthalpic and entropic contributions at Ca(2+) concentrations from <0.01 to 100 microM. At 0.15 microM Ca(2+), [(...

Journal: :The Journal of Experimental Medicine 2000
Peter U.Y. Lee Hywyn R.O. Churchill Mark Daniels Stephen C. Jameson David M. Kranz

T cell clone 2C recognizes the alloantigen L(d) and the positive selecting major histocompatibility complex (MHC), K(b). To explore the molecular basis of T cell antigen receptor (TCR) binding to different peptide/MHC (pMHC) complexes, we performed alanine scanning mutagenesis of the 2C TCR. The TCR energy maps for QL9/L(d) and SIYR/K(b) were remarkably similar, in that 16 of 41 Valpha and Vbet...

Journal: :The Astrophysical Journal 2022

Abstract Binding energies (BEs) are one of the most important parameters for astrochemical modeling determining, because they govern whether a species stays in gas phase or is frozen on grain surfaces. It currently known that, denser and colder regions interstellar medium, sulfur severely depleted phase. has been suggested that it may be locked into icy mantles. However, which main carriers sti...

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