Abstract Odorant-binding proteins (OBPs) in insects bind to volatile chemical cues that are important regulating insect behavior. It is hypothesized OBPs with specificity certain volatiles and may help transport delivery odorant receptors (ORs), buffering the olfactory response aid various behaviors. Honeybees eusocial perceive strongly rely on them perform complex Here, we have identified anno...

Cell-Selective Spider Silk Proteins In article number 2202660, Vanessa Tanja Trossmann and Thomas Scheibel design recombinant spider silk proteins to guide cell-specific materials interactions. The fusion of with short peptides from extracellular matrix such as KGD yield cell type selective binding, which enables the development hierarchically organized tissues.

background: bone morphogenetic proteins (bmps) belong to the transforming growth factor-β (tgf-β) superfamily, and play an important role in bone metabolism. recombinant forms of bmp-2 and bmp-7 are the only bmps used clinically. in this study the mature part of human bone morphogenetic protein-7 (bmp-7) was engineered through substitution of the bmp-7 n-terminal sequence by heparin-binding sit...

Abstract Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs), but specific interaction with and regulation by PIPs for most PH domain-containing proteins unclear. Here we employ a single-molecule pulldown assay study interactions of lipid vesicles full-length in mammalian whole cell lysates. Of 67 human initially examined, 36 (54%) found have affinity various specific...

We fabricated streptavidin nanoarray using annexin A5 two-dimensional crystal as a template. demonstrate specific binding of biotinylated molecules to the proteins in nanoarray.

colonization of nontypeable haemophilus influenzae (nthi) in nasopharynx causes respiratory tract disease. in 80% of clinical isolates, hmw proteins are the major adhesions and induce protective antibodies in the hosts. therefore, it can be used as a vaccine candidate. the aim of this study is designing and cloning of the conserved regions of nthi hmw1 core binding domain.in this study, the sta...

living organisms can sense and respond to external and internal stimuli. response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...