J. I. Fuks,1 N. Helbig,1 I. V. Tokatly,1,2 and A. Rubio1,3 1Nano-Bio Spectroscopy group and ETSF Scientific Development Center, Dpto. Fı́sica de Materiales, Universidad del Paı́s Vasco, Centro de Fı́sica de Materiales CSIC-UPV/EHU-MPC and DIPC, Av. Tolosa 72, ES-20018 San Sebastián, Spain 2IKERBASQUE, Basque Foundation for Science, ES-48011 Bilbao, Spain 3Fritz-Haber-Institut der Max-Planck-Gesell...

Membrane proteins are important for homeostasis of living cells, which work as ion channels, transporters, various types of chemical and biophysical sensors, and so on. These proteins are considered as important targets for biophysical studies. Our main goal is to clarify molecular mechanisms of channels, transporters and receptors in cell membrane mainly by using stimulus-induced difference in...

Consortia of Aspergillus oryzae and Saccharomyces cerevisiae are examined for their abilities to turn complex carbohydrates into ethanol. To understand the interactions between microorganisms in consortia, Fourier-transform infrared spectroscopy is used to follow the concentrations of various metabolites such as sugars (e.g., glucose, maltose), longer chain carbohydrates, and ethanol to optimiz...

Here, we report a high performance biosensor based on (i) a Cu2+-DNA/MoS2 hybrid structure and (ii) a field effect transistor, which we refer to as a bio-FET, presenting a high sensitivity of 1.7 × 103 A/A. This high sensitivity was achieved by using a DNA nanostructure with copper ions (Cu2+) that induced a positive polarity in the DNA (receptor). This strategy improved the detecting ability f...

RAMAN SPECTROSCOPY AND DIFFUSE REFLECTANCE SPECTROSCOPY FORDIAGNOSIS OF HUMAN CANCER AND ACANTHOSIS NIGRICANSby SUNEETHA DEVPURAAugust 2012Advisor : Dr. Ratna NaikCo-Advisor : Dr. Steven J. RehseMajor : Physics (Condensed Matter)Degree : Doctor of Philosophy Cancer and diabetes are common chronic diseases in today’s world causingnumerous deaths in adults as well ...

A large number of structural genomics programmes have been established worldwide with the common aim of large-scale, high-throughput protein structure determination. Due to the considerable challenges posed by the experimental methods of structural determination (primarily X-ray crystallography and nuclear magnetic resonance spectroscopy) it is important to select and prioritise candidate molec...

Interrogating individual molecules within bio-membranes is key to deepening our understanding of biological processes essential for life. Using Raman spectroscopy to map molecular vibrations is ideal to non-destructively 'fingerprint' biomolecules for dynamic information on their molecular structure, composition and conformation. Such tag-free tracking of molecules within lipid bio-membranes ca...

This article deals with the interrelationship between overall chemical speciation of S, Fe, Co, and Ni in relation to metals bio-uptake processes in continuous stirred tank biogas reactors (CSTBR). To address this topic, laboratory CSTBRs digesting sulfur(S)-rich stillage, as well as full-scale CSTBRs treating sewage sludge and various combinations of organic wastes, termed co-digestion, were t...

Conventional asphalt binder derived from the petroleum refining process is widely used in pavement engineering. However, asphalt binder is a non-renewable material. Therefore, the use of a co-production of renewable bio-oil as a modifier for petroleum asphalt has recently been getting more attention in the pavement field due to its renewability and its optimization for conventional petroleum-ba...