Peptide-amphiphiles are amphiphilic structures with a hydrophilic peptide headgroup that incorporates a bioactive sequence and has the potential to form distinct structures, and a hydrophobic tail that serves to align the headgroup, drive self-assembly, and induce secondary and tertiary conformations. In this paper we review the different self-assembled structures of peptide-amphiphiles that ra...

Background and Aim: This study aimed to compare the sorption and solubility properties of ACTIVA BioACTIVE liner and resin modified glass ionomer (RMGI).   Materials and Methods: In this in vitro study, a total of 30 samples were fabricated from each liner measuring 15 mm in diameter and 1 mm in thickness according to ISO 2009:4049. They were then divided into 6 subgroups (n=5) to assess th...

Prime task for orthopedists and traumatologists is the development of new artificial materials for replacement of osseous tissue and cartilage defects, for functional rehabilitation of the injured locomotorium tissue after traumatic fractures and surgical interventions. Electron beam (EB) processing of polymer composites with bioactive ceramics was used for manufacture of new artificial materia...

The ability to biologically manipulate musculoskeletal healing and augment bone and soft tissue repair and regeneration holds great promise. Advances in the basic science study and clinical application of bioactive proteins and growth factors continues to evolve. Improvement in the surgical resurfacing of articular cartilage defects and tendon and ligament repair through the addition of bioacti...

The synthetic thermoplastic polymer polyetheretherketone (PEEK) is becoming a popular component of clinical orthopedic and spinal applications, but its practical use suffers from several limitations. Although PEEK is biocompatible, chemically stable, radiolucent and has an elastic modulus similar to that of normal human bone, it is biologically inert, preventing good integration with adjacent b...

Delivery of bioactive factors is a very valuable strategy for articular cartilage repair. Nevertheless, the direct supply of such biomolecules is limited by several factors including rapid degradation, the need for supraphysiological doses, the occurrence of immune and inflammatory responses, and the possibility of dissemination to nontarget sites that may impair their therapeutic action and ra...

Zirconia (ZrO₂) and zirconia-based glasses and ceramics are materials proposed for use in the dental and orthopedic fields. In this work, ZrO₂ glass was modified by adding different amounts of bioactive and biocompatible hydroxyapatite (HAp). ZrO₂/HAp composites were synthesized via the sol-gel method and heated to different temperatures to induce modifications of their chemical structure, as a...

During the last decade, due to advances in functionalization chemistry, novel nanobiomaterials with applications in tissue engineering and regenerative medicine have been developed. These novel materials with their unique physical and chemical properties are bioactive hierarchical structures that hold great promise for future development of human tissues. Thus, various nanomaterials are current...

A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%-95%) or using mild MW-heating conditions (80%-91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and lu...

Submit Manuscript | http://medcraveonline.com only osteoconductivity but also osteoinductivity, has attracted much interests in the field of bone tissue engineering but not only. Indeed, the typical silicate bioactive glasses demonstrated to bond to bone more efficiently than any other synthetic materials [1]. However, it was rapidly found that the highly disrupted silica network of bioactive g...