In vitro bioassays have been developed and are currently being evaluated as potential alternatives to traditional animal toxicity models. Already, the progress of high throughput screening techniques has resulted in an enormous amount of publicly available bioassay data having been generated for a large collection of compounds. When a compound is tested using a collection of various bioassays, ...

Growth promoters play an important role in the animal agriculture industry as they facilitate to improve productivity mainly through reduction of pathogenic bacterial load in the gut. Ban and restrictions on the usage of Antibiotic Growth Promoters (AGP) due to public health concerns has made it essential to search alternatives from the herbal sources. But at the same time it is tricky to choos...

Residues dynamics of Endosulfan (525.00 g a.i. ha(-1)), Imidacloprid seed treatment (21 g a.i. kg(-1)), Lambdacyhalothrin (75.00 g a.i. ha(-1)) and Spiromesifen (225.00 g a.i. ha(-1)) in nectar and pollen of mustard, Brassica juncea (L.) Czern. grown in Himachal Pradesh (India) were determined through bioassay (using Drosophila melanogaster Meig. as test organism) and GC (Gas chromatographic) a...

In this paper, we have reported that split ring resonators (SRRs) structures can be used for bioassay applications in order to further improve the assay time and sensitivity. The proof-of-principle demonstration of the ultrafast bioassays was accomplished by using a model biotin-avidin bioassay. While the identical room temperature bioassay (without microwave heating) took 70 min to complete, t...

Two in vivo bioassay methods, a rat medium-term liver bioassay and a rat multiorgan bioassay, can be used for detecting carcinogenic or modifying potentials of endocrine active substances (EASs) on endocrine disruption (ED). The first bioassay, the rat mediumterm liver bioassay, is fundamentally based on the two-step hypothesis of liver carcinogenesis; initiation with diethylnitrosamine (DEN, 2...

To the Editor: In the October 2005 issue of Emerging Infectious Diseases, Song et al. described a fiber-optic, microsphere-based, highdensity array composed of 18 speciesspecific probe microsensors, used to identify biological warfare agents, including Clostridium botulinum (1). Although the researchers used multiple probes for C. botulinum, we doubt that this approach is suitable for this orga...

1. The OECD initiated a high-priority activity in 1998 to revise existing guidelines and to develop new guidelines for the screening and testing of potential endocrine disrupters (1). One element of the activity was to develop a Test Guideline for the rat Hershberger Bioassay. The Hershberger Bioassay is a short-term in vivo screening test using accessory tissues of the male reproductive tract....

An automated fluorescence polarization immunoassay for the determination of vancomycin levels in serum was evaluated. The vancomycin assay is a homogeneous competitive inhibition immunoassay based on changes in fluorescence polarization that occur with antibody binding. This assay was compared with a liquid chromatographic assay and an agar well diffusion bioassay method by using clinical serum...