The effect of high fat food in the steady state bioavailability of lithium carbonate (900 or 1200mg daily, in divided doses) was studied in three patients of manic-depressive psychosis in a self-control cross-over design. Serial blood samples were collected by venepuncture until 8 hours following drug administration and lithium was assayed by flame photometry. The results indicated a reduction ...

BACKGROUND Short-term measurements of iron absorption are substantially influenced by dietary bioavailability of iron, yet bioavailability negligibly affects serum ferritin in longer, controlled trials. OBJECTIVE Our objective was to test the hypothesis that in men fed diets with high or low iron bioavailability, iron absorption adapts to homeostatically maintain body iron stores. DESIGN He...

Phytases are enzymes of great industrial importance with wide range of applications in animal and human nutrition. These catalyze the hydrolysis of phosphomonoester bonds in phytate, thereby releasing lower forms of myo-inositol phosphates and inorganic phosphate. Addition of phytase to plant-based foods can improve its nutritional value and increase mineral bioavailability by decreasing nutrit...

Maximizing oral bioavailability is therapeutically important because the extent of bioavailability directly influences plasma concentrations and therapeutic efficacy after oral drug administration. Bioavailability of poor bioavailable drugs can be increased from the many available approaches in the literature and the most recent approach is the use of bioavailability enhancers. The use of bioen...

BACKGROUND Vascular nitric oxide (NO) bioavailability is reduced in patients with coronary artery disease (CAD). We investigated whether oral L-arginine, the substrate for NO synthesis, improves homeostatic functions of the vascular endothelium in patients maintained on appropriate medical therapy and thus might be useful as adjunctive therapy. METHODS AND RESULTS Thirty CAD patients (29 men;...