Work on radioautographic localization of RNA synthesis has been reviewed by Prescott (1). The findings with this method show good correspondence with biochemical evidence by indicating the nucleus as the presumptive site of RNA synthesis, and the probability of transport of RNA from the nucleus to the cytoplasm has been established. The method has been applied by Nossal et al. (2) in semiquanti...

DNMT3 proteins are de novo DNA methyltransferases that are responsible for the establishment of DNA methylation patterns in mammalian genomes. Here, we have determined the crystal structures of the ATRX-DNMT3-DNMT3L (ADD) domain of DNMT3A in an unliganded form and in a complex with the amino-terminal tail of histone H3. Combined with the results of biochemical analysis, the complex structure in...

Plant organisms possess a complex set of defence mechanisms that are responsible for preventing unfavourable interactions with other living organisms in their natural environment or for reducing negative effects of such interactions. They can be classified into two groups: early responses that occur immediately or shortly after contact with a pathogenic organism, usually in the proximity of the...

The histochemical effects of the lipid and the biochemical analysis of cholesterol content induced by mancozeb, a widely used fungicide in India and in Madhya Pradesh were observed on Swiss albino mice (Mus musculus albinicus). Three groups were used for the present experiment, where Group I was taken as control and was administered distilled water. Group II and III were the test groups receivi...

BACKGROUND Recently, a mutation in the lipoprotein lipase (LPL) gene (N291S) has been reported in 2% to 5% of individuals in western populations and is associated with increased triglyceride (TG) and reduced HDL cholesterol (HDLC) concentrations. METHODS AND RESULTS Here we report a significant alteration in biochemical and clinical phenotype in subjects with familial hypercholesterolemia (FH...

Mental retardation is the most common phenotypic abnormality seen in Down's syndrome (DS) patients, yet the underlying mechanism remains mysterious. DS critical region 1 (DSCR1), located on chromosome 21, is overexpressed in the brain of DS fetus and encodes an inhibitor of calcineurin, but its physiological significance is unknown. To study its functional importance and role in mental retardat...