leukodystrophies are metabolic disorders of the brain, spinal cord and, in part, of the peripheral nerves that lead to degeneration of the white matter (myelin) of the brain. since mainly nerve tracts, which control voluntary movement, are embedded in myelin, patients with leukodystrophy suffer from progressive movement disorders and later also from mental deterioration. through a survey, we ca...

This review addresses the potential role of omega-3 fatty acids in mood disorders, from the biochemical rationale for their use to the growing body of data supporting their clinical efficacy.

Recent advances in the identification of the neural circuits, neurochemicals, and signal transduction mechanisms involved in the pathophysiology and treatment of mood disorders have led to much progress toward understanding the roles of genetic factors and psychosocial stressors. The monoaminergic neurotransmitter systems have received the most attention, partly because of the observation that ...