Introduction. Telmisartan is widely used in clinical practice during hypertension treatment. It a specific angiotensin II receptor antagonist (type AT1), effective at oral intake, A bioequivalence study of Telzap ® and Mikardis was conducted with 60 volunteers. Aim. The purpose the trial comparative pharmacokinetics evidence (telmisartan, tablets 80 mg, Boehringer Ingelheim International GmbH, ...

The paper is devoted to various aspects of the organization drug pharmacokinetics research both at preclinical and clinical levels (bioequivalence study, therapeutic monitoring, optimization dosage regimens), as well arrangement work equipment (instrumentation, chemicals, premises, personnels) pharmacokinetic laboratory.

Article history: Received on: 21/03/2016 Revised on: 11/06/2016 Accepted on: 17/07/2016 Available online: 26/09/2016 The objective of the present study was to compare and evaluate the economic benefits and in-vitro bioequivalence of different marketed generic ciprofloxacin tablets against the innovator tablet formulation that are present in the local market of Saudi Arabia. The comparative bioe...

The aim of the study was to evaluate if two capsules (Amoxil(®) capsules, 500 mg/capsule) and one tablet (Amoxicare(®) tablets, 1000 mg/tablet) of amoxicillin have similar bioequivalence parameters. For this purpose a randomized, two-way, crossover, bioequivalence study was performed in 24 healthy, male volunteers, divided into two groups of 12 subjects each. One group was treated with the refe...

Background: Development of simple, rapid, and sensitive assay for the determination of loratadine in order to investigate its pharmacokinetic parameters in human plasma and its application in bioequivalence study of Loratadine 10mg Oral Disintegrated Tablets manufactured locally (test) and originally (Reference). Methods: After extraction of loratadine from human plasma, it was chromatographed ...

BACKGROUND The aim of this study was to determine the bioequivalence of generic (test) and branded (reference) formulations of betamethasone injectable suspension in healthy Iranian subjects for the purpose of meeting regulatory requirements for bioequivalence of the generic formulation in Iran. METHODS 24 healthy Iranian male volunteers were participated for this single-dose, randomized, ope...

Olanzapine is an atypical antipsychotic drug, used for the management of schizophrenia and for the treatment of moderate to severe mania associated with bipolar disorder. The objective of the present randomised, crossover study was to compare the bioavailability of olanzapine 10 mg/5 ml powder for oral suspension with olanzapine 10 mg orally disintegrating tablet. Eighteen healthy male voluntee...

Introduction. A fixed dose combination of telmisartan and hydrochlorothiazide is indicated for treatment in the arterial hypertension. The these substances causes an additive effect that helps to reduce blood pressure. bioequivalence study Telzap ® Plus compared with MikardisPlus was conducted 63 volunteers. Aim. purpose trial a comparative pharmacokinetics evidence drug product (tablets 80 mg ...