Dopaminergic signaling is one of the regulatory pathways being investigated for its implication in glucose metabolism. The aim of this study was to determine the effect of cabergoline on biochemical and anthropometric parameters in prediabetes stage (impaired fasting glucose and impaired glucose tolerance). In this double blind, placebo-controlled, pilot study, 27 prediabetic adults were random...

• Chemical Exchange Saturation Transfer (CEST) based Magnetic Resonance Imaging (MRI) methods inherently have superior sensitivity to molecular changes in tumors. • CEST MRI provides unconventional and in many cases molecular specific image contrast. CEST contrast can be turned on and off. • CEST MRI is sensitive to pH and molecular changes in tumors. • It enables the differential diagnosis bet...

The development of molecularly targeted anticancer therapies has resulted in a paradigm shift in the clinical drug development process. Phase 1 studies now routinely incorporate pharmacodynamic biomarker endpoints, specifically to evaluate whether a targeted therapy has the desired impact on its target and whether this leads to clinical benefit. Non-invasive molecular imaging using positron emi...

Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Growing evidence indicates that various dietary polyphenols may influence carbohydrate metabolism at many levels. In animal models and a limited number of human ...

glucose, as the major energy source in cellular metabolism, plays an important role in the natural growth of cells. herein, a simple, rapid and low-cost method for the glucose determination by utilizing glucose oxidase and cdte/thioglycolic acid (tga) quantum dots (qds) on a thin layer chromatography (tlc) plate has been described. the detection was based on the combination of the glucose enzym...

Background and Aims: Insulin is the key regulator of glucose metabolism, but it difficult to dissect direct insulin from glucose-induced effects. We aimed investigate effects hyperinsulemia on metabolomic measures under euglycemic conditions in nondiabetic participants.

BACKGROUND Erigeron breviscapus, a well-known traditional Chinese medicinal herb, is broadly used in the treatment of cerebrovascular disease. Scutellarin, a kind of flavonoids, is considered as the material base of the pharmaceutical activities in E. breviscapus. The stable and high content of scutellarin is critical for the quality and efficiency of E. breviscapus in the clinical use. Therefo...

Introduction: Many of the diseases of adulthood are originated from the intrauterine conditions during fetal life. Because of the importance of thyroid hormones in growth and development of the fetus, the effects of maternal hypothyroidism on carbohydrate metabolism in adulthood was investigated. Methods: Pregnant rats were divided into the fetal hypothyroidism (FH) and the control (C) group...

BACKGROUND The association of prediabetic states with endothelial dysfunction measured by flow-mediated dilation (FMD) or endothelial biomarker levels remains controversial. We examined data from 5 ethnic groups to determine the association between glucose categories and FMD or endothelial biomarkers. We determined whether these associations vary by ethnic group or body mass index. METHODS AN...