Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen activator inhibitor-1 (PAI-1) have recently been implicated as individual mediators in non-fibrinolytic processes, including cell adhesion, migr...

The surface of biomaterials used as implants are highly susceptible to bacterial colonization and subsequent infection. The amount of protein adsorption on biomaterials, among other factors, can affect the nature and quality of biofilms formed on them. The variation in the adsorption time of the protein on the biomaterial surface produces a phenotypic change in the bacteria by alteration of the...

It has been widely reported that chemical, structural or mechanical signals of biomaterials can impact cell behaviors and tissue regeneration, but few studies have investigated the effects of biomaterial signals on cell–cell interactions although communications between cells are critical for tissue regeneration. Our recent studies have shown that chemical signals of bioglass (BG) can stimulate ...

In the current chapter, digital morphometric analysis (DMA) was used to quantify two markers of biocompatibility around commonly used biomaterials. In the field of biomaterial evaluation for biocompatibility, more sophisticated methods are now being used to precisely characterize the elicited response from the surrounding tissue towards the implanted material. One reason for this is due to the ...