Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of vectors to distant sites, and immune responses. Viral vectors can be combined with biomaterials either through encapsulation within the material or i...

Strategies for bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and function. Of particular interest are nanocomposites and organic-inorganic (O/I) hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive inorganic materials. In this pa...

Stress urinary incontinence (SUI) and pelvic organ prolapse (POP) are major health issues that detrimentally impact the quality of life of millions of women worldwide. Surgical repair is an effective and durable treatment for both conditions. Over the past two decades there has been a trend to enforce or reinforce repairs with synthetic and biological materials. The determinants of surgical out...

In tissue engineering, biomaterials play a critical role, act as a 3D template, provide mechanical support, and give artificial extracellular matrix environment (ECM) for neo-tissue formation. Only one type of biomaterials is not enough for both hard and soft tissue engineering. That’s why all types of biomaterials i.e. metals, ceramics, & polymers have their own importance in making tissue eng...

Synthetic biomaterials are widely used in medical implants with success in improving and extending quality of life. However, these materials were not originally designed to interact with cells through specific signaling pathways. As a result, the interaction with the body is mediated through passive adsorption of a disorganized protein monolayer. Next generation biomaterials have been proposed ...

A comparative study of the effect of ultrashort (0.5 ps) and short (15 ns) pulses on the laser forward transfer of DNA molecules is presented in this paper. We use femtosecond laser pulses to directly print a wide range of biomaterials, in complicated patterns and structures. The ultrashort laser pulses reduce the thermal effects, thus allowing the effective deposition of sensitive biomaterials...

BACKGROUND Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians' reconstructive armory. Current clinically available reconstructive options have certain advantages, but also several drawbacks that prevent them from gaining universal acceptance. A wide range of synthetic and natural biomaterials is being used to develop tiss...

Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the patient specific treatment in regenerative medicine. Overexpression of diverse factors such as general reprogramming factors or lineage specific transcription factors can change the fate of al...

Biomaterials are currently applied in increasingly complex areas such as tissue engineering, bioprinting and regenerative medicine. To this end, challenging combinations of biomaterial properties required which usually cannot be met by conventional biomaterials. Since the early 2000s, several new concepts have been proposed to render biomaterials self-healing order improve functionality traditi...

Hemorrhage control is vital for clinical outcome after surgical treatment and prehospital trauma injuries. Numerous biomaterials have been investigated to control surgical and traumatic bleeding. A comprehensive review has been conducted in the area focused on the topical biomaterials for severe bleeding in prehospital settings. Solid biopolymers and ceramics are most promising materials for le...