We review our ongoing work on deploying optical (atomic) magnetometry for measuring the magnetic response of magnetic nanoparticle (MNP) samples, yielding MNP size distributions, and other sample parameters like Néel relaxation time τ , saturation magnetisation Ms, anisotropy constant K and magnetic susceptibility χ. We address magnetorelaxation (MRX) signals, in which the decaying magnetisatio...

Three-dimensional (3D) diffuse optical tomography is known to be a nonlinear, ill-posed and sometimes under-determined problem, where regularization is added to the minimization to allow convergence to a unique solution. In this work, a generalized least-squares (GLS) minimization method was implemented, which employs weight matrices for both data-model misfit and optical properties to include ...

Implantable image sensors have several biomedical applications due to their miniature size, light weight, and low power consumption achieved through sub-micron standard CMOS (Complementary Metal Oxide Semiconductor) technologies. The main applications are in specific cell labeling, neural activity detection, and biomedical imaging. In this paper the recent research studies on implantable CMOS i...

High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible ...

Biomedical imaging is a rapidly growing field to provide a state-of-the-art tool for preclinical biomedical research and clinical applications, in view of its ability to noninvasively reveal subtle structural variations of biological tissues and visualize in vivo physiological and pathological processes at the cellular and molecular levels. Mathematical methods are involved with imaging theorie...

Fluorescent 'intravital' imaging is a new research technique by which the interior of living tissues and organs (in living bodies, if possible) can be observed, revealing the kinetics of cell and molecular processes in real time. Recent technological innovations in optical equipment and fluorescence imaging techniques have enabled a variety of cellular phenomena in different tissues and organs ...

Molecular imaging is a novel technology to visualize biological processes at the cellular and molecular levels, which is reshaping both biomedical research and clinical practice. By providing molecular information to supplement and augment conventional anatomy-based imaging, molecular imaging is expected to allow 1) the earlier detection of diseases, 2) precise evaluation of disease stages, and...

Optical imaging with spectroscopic vibrational contrast is a label-free solution for visualizing, identifying, and quantifying a wide range of biomolecular compounds in biological materials. Both linear and nonlinear vibrational microscopy techniques derive their imaging contrast from infrared active or Raman allowed molecular transitions, which provide a rich palette for interrogating chemical...

Optical Coherence Tomography (OCT) is a novel biomedical imaging technique which uses lowcoherence optical interferometry to obtain micron-scale resolution tomographic images of subsurface tissue structure noninvasively. We have developed OCT scanners compatible with minimally invasive delivery technologies (i.e., biomicroscopy, endoscopy) capable of imaging up to video rate. Clinical studies o...

The importance of polarization aberrations has been recognized and studied in numerous optical systems related applications. It is known that are particularly crucial certain photogrammetry microscopy techniques to vectorial information—such as imaging, stimulated emission depletion microscopy, structured illumination microscopy. Hence, a reduction would be beneficial different types imaging/se...