Currently, Nasal drug delivery has been recognized as a very promising route for delivery of therapeutic compounds including biopharmaceuticals 1 . Nasal administration is a logical choice for topical nasal treatments such as antihistamines and corticosteroids. The nasal mucosa has also received attention as a viable means of systemic administration of analgesics, sedatives, hormones, cardiovas...

1. Kythera Biopharmaceuticals I. Dermatologic and ophthalmic drugs advisory committee briefing document: ATX-101 (deoxycholic acid) injection. https:// www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DermatologicandOphthalmicDrugsAdvisoryCommittee/UCM436604.pdf. Accessed February 26, 2017. 2. Dayan SH, Humphrey S, Jones DH, et al. Overview of ATX-101 (Deoxycholic Acid ...

The group of protein drugs has been developing very strongly, promising great advances in diagnosis, treatment, prevention, and human health improvement. Protein drug production is a large area research, requiring advanced scientific technological expertise, integration multi-disciplinary technology from fields such as biology, genetics, biotechnology, extraction purification, pharmaceutical ma...

Einar M. Sigurdsson,1,2 Elin Knudsen,1 Ayodeji Asuni,1 Cheryl Fitzer-Attas,4 Daniel Sage,1 David Quartermain,3 Fernando Goni,1,5 Blas Frangione,1,2 and Thomas Wisniewski1,2,3 Departments of 1Psychiatry, 2Pathology, and 3Neurology, New York University School of Medicine, New York, New York 10016, 4Mindset BioPharmaceuticals, Jerusalem 91450, Israel, and 5Department of Immunology, University of U...

Peptides show great pharmaceutical potential as active drugs and diagnostics in several clinical areas such as endocrinology, urology, obstetrics, oncology, etc. and as functional excipients in drug delivery systems to overcome tissue and cellular membrane barriers (Nestor, 2009). From a pharmaceutical point of view, peptides are situated somewhere between classical organic drug substances and ...

In vitro protein refolding is still a bottleneck in both structural biology and in the development of new biopharmaceuticals, especially for commercially important polypeptides that are overexpressed in Escherichia coli. This review focuses on protein refolding methods based on column procedures because recent advances in chromatographic refolding have shown promising results.

Introduction: Biologics (biopharmaceuticals) present new promising therapies for many diseases such as cancers, chronical inflammatory and today's biggest challenge - COVID-19. Research: Today, most biologics have been synthetized using modern methods of biotechnology, in particular DNA recombinant technology. Current pharmaceutical forms protein/peptide biopharmaceuticals are intended parenter...