One of the major steps toward the industrialization of the microbial product(s) is to optimize the cultivation conditions at the large-scale bioreactor and successfully control the microbial behavior within a large scale production environment. Statistical Design of Experiment was proven to optimize a vast number of microbial processes to achieve robustness and explore possible interactions...

a laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. six impeller combinations consisting of three basic impeller types, namely rushton turbine (rt), pitched 4blade (p4b) and pitched 2blade (p2b) downward flow were investigated in 1.77 l bioreactor working volume. power consum...

background: leachatecontaining high levels of organic pollution with ammonia, halogenatedhydrocarbons, heavy metals and inorganic salts. among the various methods fortreating leachate, has been developed membrane processes so that a morebiological process of membrane processes is used for separation of solid -liquid. the aimof this study was to evaluate the efficiency of membrane bioreactor eff...

in this paper, the fuzzy system has been used for fault detection and diagnosis of a yeast fermentation bioreactor based on measurements corrupted by noise. in one case, parameters of membership functions are selected in a conventional manner. in another case, using certainty factors between normal and faulty conditions the optimal values of these parameters have been obtained through the genet...

Mesenchymal stromal cell (MSC)-derived products, such as trophic factors (MTFs), have anti-inflammatory properties that make them attractive for cell-free treatment. Three-dimensional (3D) culture can enhance these properties, and large-scale expansion using a bioreactor reduce manufacturing costs. Three lots of MTFs were obtained from umbilical cord MSCs produced by either monolayer (Monol MTF...

Heavy metals are necessary at low concentration for biological activity, but they often toxic microorganisms high concentrations. Amplicon sequencing of 16S rRNA and 18S was used to investigate changes in the bacterial microeukaryotic communities an activated sludge bioreactor incrementally contaminated with nickel (Ni), copper (Cu), zinc (Zn) IC 50 value ranging from 0% 100%, as previously det...