BACKGROUND Insulin is an effective treatment for achieving glycemic control and preventing complications in patients with diabetes. In order to make insulin therapy more acceptable to patients, newer formulations of insulin have been developed, such as biphasic insulins. Biphasic insulins conveniently provide both prandial and basal insulin in a single injection. One of the most well-studied bi...

When a tracer substance which does not diffuse through the capillary walls is introduced into the brachial artery and the effluent blood is sampled continuously thereafter, a time-concentration curve of the labeled substance may be plotted which describes the velocity-flow pattern of the blood in the forearm ( 1) . It was found that the descending limb of the time-concentration curve usually wa...