how to cite this article: karimzadeh p, ghazavi a. comparison of deflazacort and prednisone in duchenne muscular dystrophy. iranianjournal of child neurology 2012;6(1):5-12. objective duchenne muscular dystrophy (dmd) is a degenerative disease that usually becomes clinically detectable in childhood as progressive proximal weakness. no cure is yet available for dmd, but the use of steroids impro...

Clinical trials provide the evidence that forms one of cornerstones modern evidence-based medicine, together with clinical judgement and patient values preferences.1Evidence-Based Medicine Working GroupEvidence-based medicine: a new approach to teaching practice medicine.JAMA. 1992; 268: 2420-2425Crossref PubMed Scopus (3361) Google Scholar The US National Institutes Health defines trial as, ‘a...

NeoDoppler is a noninvasive monitoring device that can be attached to patient's head provide real-time continuous cerebral Doppler evaluation. A feasibility study shows it used in operating theatres during anaesthesia potentially guide haemodynamic management. We discuss the impact of this new and which further research would necessary find its role clinical practice. In June 2023 issue BJA Ope...

There are two papers in this issue of the British Journal of Anaesthesia which look at h-index —one in UK academic departments of anaesthesia and the other in anaesthesia journals’ editorial board members. The concept of h-index has rapidly been elevated to great importance in the UK because of changes in the way money will be distributed to Universities through the Research Excellence Framewor...

Editor—We were surprised to read the letter of Bellomo and colleagues criticizing the Co-ordination Group for Mutual Recognition and Decentralised Procedures-human (CMDh) position related to the benefit/risk evaluation of hydroxylethyl starch (HES)-containing solutions. Since the conclusion of these EU Article 31 and 107i procedures is based on a review of all available safety and efficacy data...

Editor—The British cycling team won eight gold medals at the 2012 London Olympics. This success, it has been suggested, was attributable, in part, to philosophy of ‘the aggregation marginal gains’: small improvements every day, everywhere and anywhere, that have a compound effect. concept gained traction clinical anaesthesia perioperative medicine; we believe should likewise be applied sustaina...

Worldwide, more than 230 million major surgical procedures are performed each year. For these patients, postoperative nausea and vomiting (PONV) are among the most frequently observed adverse events associated with the provision of general anaesthesia. It is distressing to patients and impairs the quality of recovery as judged by the patients and anaesthesiologists alike. 3 Our patients obvious...

In this issue, a survey of UK intensive care units (ICUs) is described and the uptake of selective decontamination of the digestive tract (SDD) within these units is reported. Impressively, the authors achieved a 100% response from all the units contacted, but out of the total of 250, only three reported using a full SDD protocol including i.v. antibiotics, 10 more (13 in total) reported using ...

Editor—We thank Jayaram and Manickam for their e-letter in the BJA online, and also a letter in the Bulletin in response to our article, and note that they identify several important issues relating to airway management in intensive care unit (ICU). We agree that airway interventions in critically ill patients are associated with an increased rate of difficulty and complications. 4 Our survey s...

The concept that one could replace a body part from another of the (autograft) or even person (homograft) has been around for millennia. In fact, autogenous skin flaps were carried out as far back sixteenth century. But it is only in 20th century better understanding immunology clarified reasons observation homograft failure, due to groundbreaking work Billingham, Brent, and Medawar. Using an i...