INTRODUCTION Incontinentia pigmenti is a rare X-linked dominant disease which affects the ectodermal tissues, usually lethal in males. MATERIALS AND METHODS A retrospective analysis of clinical data obtained from the photographic documentation and casenotes of patients diagnosed to have incontinentia pigmenti at the National Skin Centre. The study covered the period from January 1990 to Decem...

Mammalian organs are known to decarboxylate a number of n-amino acids. Of the mammalian decarboxylases, 3,4-dihydroxyphenylalanine decarboxylase is probably the most studied. Blaschko (1) reported values for DOPAl decarboxylase in .liver and kidney of several animal species. The enzyme was shown to be deactivated by dialysis and its activity restored by the addition of pyridoxal phosphate (2, 3...

<p class="abstract">Lupus panniculitis of scalp is an uncommon manifestation lupus erythematosus, which presents as non-scarring linear, arched, or annular alopecia along the lines Blaschko. A 7 year old child presented with localised linear on scalp. Examination revealed a single alopecic patch left parietal There were no associated systemic complaints. Skin biopsy showed atrophic lining...

Lichen planus pigmentosus (LPP) is chronic pigmentary disorder that shows diffuse or reticulated hyperpigmented, dark brown macules on the sun-exposed areas such as the face, neck and other flexural folds. Clinically, it is different from classical lichen planus because LPP has a longer clinical course and it manifests with dark brown macules. In case of LPP, involvement of the scalp, nail or m...

The term hypomelanosis of Ito (HI) is applied to individuals with skin hypopigmentation along the lines of Blaschko. Although it was originally described as a purely cutaneous disease, subsequent studies describing HI reported a 33% to 94% association with multiple extracutaneous manifestations, mostly of the central nervous and musculoskeletal systems. This leads to characterization of HI as a...

We report on a 15-year-old female with a 3-month history of a pruritic, erythematous cutaneous eruption on the right cheek and perioral area. The lesion had a linear distribution following the lines of Blaschko. Histopathological findings and direct immunofluorescence were compatible with chronic cutaneous lupus erythematosus (LE). Treatment with topical steroids and systemic antimalarial agent...

The association of microphthalmia and linear skin defects was named microphthalmia with linear skin defects syndrome (MLS) or MIDAS syndrome (microphthalmia, dermal aplasia, and sclerocornea), an X-chromosomal disorder manifesting mainly in females. We examined a female newborn with facial linear skin defects following the Blaschko lines. Computer tomography and ophthalmological examination con...

A 34 year man presented to us with itchy lesions on one half of the trunk for the past two months. The lesions started as erythematous to violaceous papules and plaques on the flank and gradually increased in number to involve the left side of the trunk (Figure 1 and 2). Some areas showed the Koebner phenomenon. These lesions were distributed along the lines of Blaschko. Examination of the oral...