Blast-related traumatic brain injury (TBI) has received much recent attention because of its frequency in the conflicts in Iraq and Afghanistan. This renewed interest has led to a rapid expansion of clinical and animal studies related to blast. In humans, high-level blast exposure is associated with a prominent hemorrhagic component. In animal models, blast exerts a variety of effects on the ne...

Explosion and fire on an offshore rig can lead to its minor or complete damage and sinking which means the loss of life or environmental pollution. Hence the use of techniques such as blast wall is crucial to reduce the detrimental effects. These blast walls are designed for explosion wave of length between 0.1 to 1 of load mainly to protect the personnel and critical sections. In this research...

Despite recent efforts to understand blast effects on the human brain, there are still no widely accepted injury criteria for humans. Recent animal studies have resulted in important advances in the understanding of brain injury due to intense dynamic loads. However, the applicability of animal brain injury results to humans remains uncertain. Here, we use advanced computational models to deriv...

while significant advances have been made on the blast analysis, applications of nonlinear analysis of structures under explosion have been limited to the frames and structural behavior of bridges subjected to blast is an issue that has attracted attention of researchers in recent years. nonlinear dynamic analysis can be lead to the most accurate responses of the structure under blast but the u...

The role of primary blast in blast-induced TBI is controversial. The identification of well documented clinical cases is difficult and rare, while the technical difficulties associated with simulating primary blast in the laboratory are considerable, resulting in an inconsistent literature that is difficult to interpret. This laboratory initiated a multidisciplinary effort in order to understan...

Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequence-search (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low sequence identity is not known. We have used the CE structure alignment program (Shindyalov and Bo...

BACKGROUND No evidence-based guidelines are available for the definitive diagnosis or directed treatment of most blast-associated traumatic brain injuries, partly because the underlying pathology is unknown. Moreover, few neuropathological studies have addressed whether blast exposure produces unique lesions in the human brain, and if those lesions are comparable with impact-induced traumatic b...

An essential problem for the biologist is the processing and evaluation of BLAST query results. We advocate the deployment of database technology and describe a user-driven tool, called BlastQuest. BlastQuest provides interactive, Web-enabled query, analysis, and visualization facilities beyond what is possible by current BLAST interfaces. Specifically, the BLAST results are extracted, structur...

Basic local alignment search tool (BLAST) is a sequence similarity search program. The National Center for Biotechnology Information (NCBI) maintains a BLAST server with a home page at http://www.ncbi.nlm.nih.gov/BLAST/. We report here on recent enhancements to the results produced by the BLAST server at the NCBI. These include features to highlight mismatches between similar sequences, show wh...