Bleomycin là một lại kháng sinh chống ung thư có nguồn gốc Streptomyces Verticillus. Độc tính trên da của không thường gặp như độc phổi. Viêm hình roi hiếm nhưng đặc trưng, với tỉ lệ xuất hiện khoảng 8 - 22%. Sau đây, chúng tôi xin báo cáo trường hợp viêm do Bleomycin. Bệnh nhân nữ, 20 tuổi, vào viện vì hạch cổ to kèm sốt thất thường, gầy sút cân. được chẩn đoán: U lympho Hodgkin giai đoạn IVBS...

Abstract Idiopathic pulmonary fibrosis (IPF) is a serious and irreversible chronic lung disease. Bleomycin (BLM) an anticancer drug, which can cause severe toxicity. The main target of oxidative stress-induced injury alveolar epithelial cells, lead to interstitial fibrosis. present study investigated whether hispidin (HP), has excellent antioxidant activity, attenuates bleomycin-induced via ant...

Oxidative stress plays an important role in the development of fibrotic responses in the lung. However, it is not clear whether inhibiting oxidative stress with antioxidants can attenuate fibrotic processes in the lung. The objective of these studies was to test whether the catalytic antioxidant porphyrin manganese (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP) could protect mice against bl...

Idiopathic pulmonary fibrosis is a devastating disease characterized by a progressive, irreversible, and ultimately lethal form of lung fibrosis. Except for lung transplantation, no effective treatment options currently exist. The bleomycin animal model is one of the best studied models of lung injury and fibrosis. A previous study using mouse tumor models observed that liposome-encapsulated bl...

Low-molecular-weight phleomycin (Mr approximately 1500-1600) is considerably less active on a per mol basis than structurally related bleomycin in degrading purified Saccharomyces cerevisiae DNA. Phleomycin also exhibits a substantially higher requirement than bleomycin for ferrous ions. However, phleomycin (0.13 to 3.3 x 10(-6) M) produced 7 to 350 times more breaks than bleomycin in prelabele...

Studies of human tissue have suggested an association between productive Epstein Barr virus and idiopathic pulmonary fibrosis (IPF). However, a pathogenic role for the virus has not been established. This study was undertaken to develop an animal model, which would explore the association between viral infection and pulmonary fibrosis. BALB/c mice (n=30), resistant to bleomycin, were primed wit...

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still no cure for this disease. Pre-clinical animal models are currently largely limited to small animals which have a number of shortcomings. We have previously shown that fibrosis is induced in isolated sheep lu...

Ortiz, Luis A., Hunter C. Champion, Joseph A. Lasky, Federica Gambelli, Evelyn Gozal, Gary W. Hoyle, Mary B. Beasley, Albert L. Hyman, Mitchell Friedman, and Philip J. Kadowitz. Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NFB and AP-1. Am J Physiol Lung Cell Mol Physiol 282: L1209–L1221, 2002. First published January 12, 2002; 10.1152/ajplung.001...

Bleomycin is well known as causative molecule for acute lung injury and interstitial pneumonia. The free radical production from bleomycin is thought to play an important role in the pathogenesis of acute lung injury and interstitial pneumonia. However, there was no direct evidence of free radical production in this model. Therefore, we examined in vivo radical production by mice treated with a...