Nucleotide sequences of each variable block in the Plasmodium falciparum merozoite surface protein-1 gene (PfMSP-1) may be grouped into one of two or three possible allelic types, named after the reference isolates MAD20, K1, and RO33. Allelic diversity at this locus basically results from different combinations of allelic types in variable blocks. We used a polymerase chain reaction (PCR)-base...

The increased incidence of cancer in children and adolescents registered in Italy in the last few decades is one of the highest amongst Western countries. The causes are difficult to identify, but recent daily news and some epidemiological surveys, such as the ‘Sentieri’ study, suggest that environmental pollution has an important role. In the past 20 years, epigenetic studies have described ho...

Technology has been playing a very important role in the advancement of science, and big breakthroughs science are dependent upon technologies available from time to time. Between technology, good understanding is required so that can be used most efficiently effectively solving targeted questions scientific research. Genome nucleotide sequencing as an technology after several generations techn...

The process of developing an iron ore mine from exploration data through to informed mining decisions provides an example of a Complex Adaptive System. The detailed composition of an ore body (expressed as a “block model” of regularly spaced rectangular blocks) has to be estimated from initially sparse exploration data, based upon a limited number of drill holes. As planning proceeds, the data ...

the product rate variation problem minimizes the variation in the rate at which different models of a common base product are produced on the assembly lines with the assumption of negligible switch-over cost and unit processing time for each copy of each model. the assumption of significant setup and arbitrary processing times forces the problem to be a two phase problem. the first phase determ...

introduction: hepatitis c virus (hcv) is the major cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. because of increasing number of infected patients throughout the world, various studies are concentrated on development of high quality diagnostic tests and genotyping in various regions of the world. methods: in this study, we used rt-pcr to isolate and a...

objective: since the identification of the two highly penetrant dominantly inherited genes, brca1/2, in the 1990s, a number of other genes have been identified which account for approximately 25% of the genetic basis for hereditary breast cancer. at least 75% are unidentified. the goal of this study is to investigate the presence or absence of a recessive pattern of inheritance in this heteroge...