The development of high-titer inhibitors to FVIII and less often to other coagulation factors are the most serious complication of hemophilia therapy and makes treatment of bleeds very challenging. At present, bypassing agents, such as factor eight inhibitor bypass activity (FEIBA) and activated recombinant factor VII (rFVIIa) are the only coagulation factor concentrates available for the treat...

The coagulation process interpreted as a second order reaction and it is assumed that the intensity of scattered light on the colloidal particles follows the Raileygh eq. At each collision of two aggregates the smaller aggregate loses a given number of primary particles while the bigger aggregate increases by the same number of primary particles. The »critical time« (terit) is determined by the...

.................................................................................................................................................. 5 Sammanfattning på svenska ................................................................................................................... 7 Original papers ...........................................................................................

PURPOSE The aim of this study was to investigate prophylactic treatment effects in Korean patients with severe hemophilia A. METHODS A prospective study of 32 severe hemophilia A patients was conducted with the approval of the Institutional Review Board at the Eulji University Hospital. Two patients received primary prophylaxis; whereas, the other 30 patients were divided into 2 groups-second...

Microwave coagulation therapy (MCT) has been employed mainly for treatment of small size tumors. In the treatment, thin microwave antenna is inserted into the tumor and microwave energy heats up the tumor up to at least 60 degrees C for generation of enough coagulated volume including the target tumor. During the microwave radiation, reflection coefficient of treatment antenna changes significa...

PJIHE INTRODUCTION of rapid, simple methods for measuring the specific gravity of body fluids ’ has led to a growing appreciation of the usefulness of such measurements, particularly as applied to blood and plasma.’’#{176} Although it is not difficult to measure the specific gravity of blood prior to coagulation, the comparable treatment of plasma requires special facilities for rapid sedimenta...

BACKGROUND Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated ...

By JAMES G. WmTE, WILLIAM KRIVIT AND ROBERT VERNIER T HE PRIMARY PURPOSE of the complex mechanism of coagulation is to convert soluble fibrinogen molecules into a stable meshwork of fibrin. Appreciation of the macro-molecular architecture of fibrin is essential to an understanding of how clot formation fulfills its role in hemostasis. An electron microscopic study, combining the use of immune m...