We have investigated the effect of 5-hydroxytryptamine (5HT) on SMT-2A mammary adenocarcinoma blood flow during localized microwave hyperthermia treatment. Tissue blood flow in isogeneic female W/Fu rats was estimated using 25-fimdiameter 113Sn-labeled microspheres. An intraarterial injection of 5-HT (1 mg/kg) into either conscious or anesthetized (Nembutal, 20 mg/kg) animals resulted in a 53% ...

BACKGROUND AND OBJECTIVES Page's (1994) prominent theory for the explanation of fainting in blood-injection-injury situations holds that disgust sensitivity contributes to syncopal reactions. We investigated if blood donation-related vasovagal symptoms (1) or fainting related to blood donations (2) are associated with disgust sensitivity. METHODS In an online sample of 361 blood donors, we as...

The aim of the study is to determine and compare the pharmacokinetics and tissue distribution of Doxorubicin (Dox) delivered as solution or through nanoparticles after intravenous (i.v.) and intraperitoneal (i.p.) injection. Doxorubicin loaded poly(butyl cyanoacrylate) nanoparticles were synthesized by dispersion polymerization (DP) and emulsion polymerization (EP) techniques. The drug loaded D...

OBJECTIVE The purpose of the study is to determine the effectiveness and safety of nicardipine infusion for controlling blood pressure in patients with subarachnoid hemorrhage (SAH). METHODS We prospectively evaluated 52 patients with SAH and treated with nicardipine infusion for blood pressure control in a 29 months period. The mean blood pressure of pre-injection, bolus injection and contin...

The placental transmission of lincomycin was studied in 60 patients in late pregnancy. A peak maternal blood level of 12.5 mug/ml was recorded 45 minutes after injection, and detectable levels were still present up to 42 hours after a single injection. A peak cord blood level of 2.7 mug/ml was recorded 55 minutes after injection; cord blood levels were about a quarter of the maternal blood leve...

the effect of chronic inflammation induced by complete freund's adjuvant (cfa) on anterior blood vessels of knee joint and its diameter was studied. blood flow changes in response to phenylephrine (αl-adrenoceptor agonist) in cfa-treated and contralateral knee joints were observed over a 40-day period, using laser doppler flowmetery (ldf) technique. unilateral injection of cfa (0.2 ml) inc...

introduction: ghrelin increases growth hormone secretion and food intake. growth hormone (gh), steroid hormones and opioids are involved in the regulation of food intake. so, they may have a role in the regulation of ghrelin secretion. we determined the effect of intravenous injections of progesterone, gh and morphine or co-administration of these hormones on ghrelin concentration and body weig...

To investigate the channels and neurotransmitters in the ventrolateral medulla (VLM) oblongata that are responsible for the maintenance of sympathetic tone and cardio-respiratory reflex regulation. Microinjections of excitant amino acid (glutamate, 100 nl, 100 mM), calcium channel blockers, agonists and antagonists were made throughout the VLM in anaesthetized rats. Arterial blood pressure, sym...

sir, worldwide, in the health care industry, administration of injections is one of the most frequently performed procedures.[1] the world health organization has defined “safe injection” as one which is not only harmless to the recipient, but even does not expose the provider to any risk and does not produce any waste which can be hazardous for the society.[2] in‑fact, on an annual basis, at l...