The adhesion of leukocytes to immobilised platelets may contribute to inflammatory and thrombotic responses in damaged tissue. To investigate the conditions under which platelets and leukocytes might be deposited together in vessels, we perfused fluorescently-labelled whole blood through glass capillaries coated with various collagen preparations. Video-microscopic observations of the surface s...

The existence of platelet ‘hyperreactivity’ as a trigger of acute vascular events has been postulated clinically for decades. However, the molecular nature of an intrinsically enhanced platelet function remained unknown. Recently, a possible explanation was provided in that several genetically determined variants of platelet glycoprotein receptors can be responsible for an increased thrombogeni...

abstract      background and objective: aluminum phosphide (alp) is a solid non-organic phosphide with dark gray or dark yellow crystals. it reacts with stomach acid after ingestion and causes phosphine gas to be released. it is thought that phosphine causes toxicity from enzymatic interference and may even lead to cell death. this study aimed to investigate the effects of poisoning with rice t...

Plasmalogens have now been identified in a wide variety of organisms (l-3). In studies previously reported, plasmalogens were identified and roughly quantitated (4) in human platelet phosphatides. The present report concerns a precise determination of’plasmalogens in human blood platelets with the use of techniques not previously available. An evaluation of the possible role of plasmalogens in ...

PROGRESS IN CHEMICAL TOXICOLOGY, Vol. 2 Edited by A. Stolman. (Pp. x + 416. 100s.) New York and London: Academic Press. 1965. This book follows the publication of 'Toxicology, Mechanisms and Analytical Methods', Volumes 1 and 2, in 1960-61, and Volume I of 'Progress in Chemical Toxicology' in 1963. It consists of six main chapters by seven American and two British authors. Very nearly half the ...


 Platelets are essential elements of human blood. In addition to their normal role, platelets involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation vivo, probably involves a combination agonists. Garlic has beneficial effects due its ability inhibit platelet aggregation thromboxane formation. The aim this work was evaluate the garlic extract...

The blood platelets are crucial for the coagulation physiology to maintain haemostatic balance and are involved in various pathologies such as atherosclerosis and thrombosis. The studies of recent years have shown that anucleated platelets are able to succeed protein synthesis. Additionally, mRNA translation in blood platelets is regulated by miRNA molecules. Recent works postulate the possibil...

Small, non-nuclear cells, platelets, are primarily designed to form aggregates when blood vessels damaged, stopping bleeding. To perform this function, platelets can implement several functional responses induced by various agonists and coordinated a complex network of intracellular signaling triggered dozen different receptors. This review, the second in series, describes known pathways platel...