OBJECTIVES Metabolic dysfunction is a common hallmark of the aging process and aging-related pathogenesis. Blood metabolites have been used as biomarkers for many diseases, including cancers, complex chronic diseases, and neurodegenerative diseases. METHODS In order to identify aging-related biomarkers from blood metabolites, we investigated the specific metabolite profiles of mouse sera from...

introduction: controlling and reducing serum uric acid levels may have beneficial effects on blood pressure control. the current study was carried out to assess the effects of allopurinol administration on serum uric acid and arterial blood pressure among the patients under hemodialysis.  methods: this double-blind clinical trial was conducted on 132 hemodialysis patients (two separate groups) ...

The metabolite patterns of tacrolimus in blood were evaluated in 41 kidney and liver graft recipients. Trough concentrations of tacrolimus and its metabolites were measured by HPLC-mass spectrometry and microparticle enzyme immunoassay in parallel. A statistically significant correlation between results of both assays was observed for kidney and liver transplant patients (r = 0.77, P <0.001 and...

BACKGROUND AND PURPOSE Anthocyanins are phytochemicals with reported vasoactive bioactivity. However, given their instability at neutral pH, they are presumed to undergo significant degradation and subsequent biotransformation. The aim of the present study was to establish the pharmacokinetics of the metabolites of cyanidin-3-glucoside (C3G), a widely consumed dietary phytochemical with potenti...

Metabolomics is a promising tool for discovery of novel biomarkers of chronic disease risk in prospective epidemiologic studies. We investigated the between- and within-person variation of the concentrations of 163 serum metabolites over a period of 4 months to evaluate the metabolite reliability expressed by the intraclass-correlation coefficient (ICC: the ratio of between-person variance and ...

The article presents a review of the literature on clinical aspects assessing vitamin D deficiency in young children by concentration 25(OH)D (hydroxycalciferol) blood serum. purpose was to familiarize pediatric specialists with real state affairs significance diagnosing status, its relationship prevention deficient rickets, ways correcting and choosing dose calciferol. A daily 400 IU for is ef...

Shaofu Zhuyu decoction (SFZYD, also known as Sobokchugeo-tang), a classical prescription drug in traditional East Asian medicine, has been used to treat blood stasis syndrome (BSS). Hepatic steatosis is the result of excess caloric intake, and its pathogenesis involves internal retention of phlegm and dampness, blood stasis, and liver Qi stagnation. To evaluate the effects of treatment with SFZ...

this experiment was conducted to investigate the effects of different levels of oxidized fat (yellow grease) and copper sulfate on performance, carcass traits, blood metabolites and immune cells of broilers. this study was carried out as a 3 × 2 factorial experiment with 3 levels of oxidized fat (0, 2 and 4%) and 2 levels of copper sulfate (0 and 300 mg/kg) in 6 treatments, 3 replicates and 12 ...

1 Patients and animals with chronic kidney disease (CKD) exhibit profound alterations in 2 the gut environment including shifts in microbial composition, increased fecal pH, and increased 3 blood levels of gut microbe-derived metabolites (xeno-metabolites). The fermentable dietary 4 fiber—high amylose maize resistant starch type 2 (HAMRS2)—has been shown to alter the gut 5 milieu, and in CKD ra...

PURPOSE To investigate the effect of lutein supplementation at doses of 2.5, 5.0, and 10 mg/d for 6 months on distribution of these carotenoids and their metabolites in the serum of elderly human subjects, with and without age-related macular degeneration. To determine whether supplementation with lutein can interact with the serum levels of other dietary carotenoids, retinol, and alpha-tocophe...