the regulation of fibrinolysis in the blood vessel by producing plasminogen activators and plasminogen activator inhibitors. Defects in physiological regulation of the balance of the activities between plasminogen activator and the inhibitors may cause vascular diseases such as thromboembolismand atherosclerosis. In patients with such diseases, the inhibitor may be dominant in this balance. Act...

introduction: cardiac dysfunctions have been well known in patients with major thalassemia. some studies have focused on differences in blood pressure and heart rate between these patients and normal population, while this view has not been proven in other studies. given the importance of hemodynamic factors in the health of these individuals, we intend to test the hypothesis as to whether or n...

Systemic vasculitis is a group of heterogeneous diseases characterized by inflammation and blood vessel walls necrosis. Usually the skin is one of the first organs involved, especially with damage of small to medium size vessels. The cutaneous patterns may help clinicians to diagnose these diseases at the beginning of their course, preventing complications due to internal organ involvement. ...

Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic formation. In recent decades, their key role has broadly expanded beyond physiology and pathology. Nowadays, BMP pathway is considered an important player vascular signaling. Indeed, mutations genes encoding different of cause various severe diseases. Their signaling c...

Background. Strong evidence exists showing that psychosocial stress plays an important part in the development of cardiovascular diseases. Because physical inactivity is associated with less favourable retinal vessel diameter and blood pressure profiles, this study explores whether physical fitness is able to buffer the negative effects of psychosocial stress on retinal vessel diameters and blo...

Vascular smooth muscle cells (VSMCs) are the predominant cell type within blood vessels. In normal vessels VSMC have low rates of proliferation, migration and apoptosis. However, increased VSMC proliferation, migration, and apoptosis rates radically alter the composition and structure of the blood vessel wall and contribute to vascular diseases such as atherosclerosis, in-stent restenosis and v...

Cardiovascular system diseases are the leading cause of death in developed countries. According to the World Health Organization data, coronary artery disease is responsible for death of over seven million people per year, while only in the United States about two million patients are hospitalized with the diagnosis of acute coronary syndrome (acute myocardial infarction or unstable angina). Th...

background and objective: cerebral arteriovenous malformation (cavm) hemodynamic is disease condition, results changes in the flow and pressure level in cerebral blood vessels. measuring flow and pressure without catheter intervention along the vessel is big challenge due to vessel bifurcations/complex bifurcations in arteriovenous malformation patients. the vessel geometry in cavm patients are...