Introduction / objectives The rate of bloodstream infections has been monitored monthly since 2004 at Aarhus University Hospital, Skejby. The hospital is a tertiary referral hospital with 400 beds specialising in paediatrics, gynaecology & obstetrics, urology, thoracic and vascular surgery, renal medicine, cardiology, infectious diseases and intensive care. The aim of this study was to identify...

STUDY OBJECTIVE To evaluate the relationship between the adequacy of antimicrobial treatment for bloodstream infections and clinical outcomes among patients requiring ICU admission. DESIGN Prospective cohort study. SETTING A medical ICU (19 beds) and a surgical ICU (18 beds) from a university-affiliated urban teaching hospital. PATIENTS Between July 1997 and July 1999, 492 patients were p...

We report the first four North American cases of Candida dubliniensis fungemia, including the first isolation of this organism from the bloodstream of an HIV-infected person. All isolates were susceptible in vitro to commonly used antifungal drugs. This report demonstrates that C. dubliniensis can cause bloodstream infection; however, the incidence of disease is not known.

We describe 58 adult patients with melioidosis in Cambodia (2007-2010). Diabetes was the main risk factor (59%); 67% of infections occurred during the rainy season. Bloodstream infection was present in 67% of patients, which represents 12% of all bloodstream infections. The case-fatality rate was 52% and associated with inappropriate empiric treatment.

Background: Bloodstream Infections (BSIs) that arise secondary to urinary tract infections (UTIs) are frequently encountered in both community and hospital settings associated with significant morbidity, mortality, high healthcare costs prolonged stays Objective: This descriptive review aims evaluate available information on the relationship of healthcare-associated community-onset bloodstream ...

In previous bloodstream infection studies in Malawi, we inoculated blood from a single venesection into a single BACTEC MYCO/F LYTIC (MFL) vial. Inoculation of one vial, however, would be expected to reduce the sensitivity of bloodstream pathogen detection with MFL vials. To ascertain the degree of this loss of sensitivity, blood was drawn from each of 228 febrile, adult inpatients in Malawi an...

BACKGROUND Bloodstream infections (BSI) are frequently seen after solid organ transplantation. The incidence of bloodstream infections differs among the types of transplantation. The microbiological features and antimicrobial resistance patterns change from centre to centre. AIMS To evaluate the incidence and spectrum of aetiological agents of bloodstream infections among solid organ transpla...

Bloodstream infections associated with the insertion and maintenance of central venous catheters (CVC) are among the most dangerous complications that can occur, worsening the severity of the patients’ underlying ill health, prolonging the period of hospitalisation and increasing the cost of care.1–6 Every year, almost 6,000 patients in the UK acquire a catheter-related bloodstream infection.5,...

OBJECTIVE Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis in the critically ill, it remains unclear how changes in CRP and PCT compare in predicting evolution of: infectious disease, invasiveness and severity (e.g. development of septic shock, organ failure and non-survival) in response to treatment. The current study attempts to cl...

Among critically ill patients, the diagnosis of bloodstream infection poses a major challenge. Current standard bacterial identification based on blood culture platforms is intrinsically time-consuming and slow. The continuous evolvement of molecular techniques has the potential of providing a faster, more sensitive and direct identification of causative pathogens without prior need for cultiva...