نتایج جستجو برای: bmmscs

تعداد نتایج: 206  

Journal: :Stem cells international 2016
Shutian Shi Xingxin Wu Xiao Wang Wen Hao Huangtai Miao Lei Zhen Shaoping Nie

Bone marrow mesenchymal stem cells (BMMSCs) are used in cardiac tissue engineering for the regeneration of diseased hearts. We examined the differentiation of rat BMMSCs into cardiomyocyte-like cells when induced with a combined low dose treatment of transforming growth factor-β1 (TGF-β1) and 5-azacytidine (5-AZA). Results showed that cell proliferation in the combined low dose treatment group ...

Journal: :Diabetes research and clinical practice 2011
Debin Lu Bing Chen Ziwen Liang Wuquan Deng Youzhao Jiang Shufa Li Jing Xu Qinan Wu Zhonghui Zhang Bing Xie Sihao Chen

AIMS To identify better cells for the treatment of diabetic critical limb ischemia (CLI) and foot ulcer in a pilot trial. METHODS Under ordinary treatment, the limbs of 41 type 2 diabetic patients with bilateral CLI and foot ulcer were injected intramuscularly with bone marrow mesenchymal stem cells (BMMSCs), bone marrow-derived mononuclear cells (BMMNCs), or normal saline (NS). RESULTS The...

ژورنال: Anatomical Sciences Journal 2009
Piriaei, Abbas , Baharvand , Hossein, Rezazadeh Valoujerdi, Mojtaba,

Purpose: To study the effect of allogenic bone marrow mesenchymal stem cells (BMMSCs) transplantation on carbon tetrachloride-induced liver fibrosis in mice. Materials and Methods: Fifty five female NMRI mice were divided in 5 groups, and to induce liver fibrosis CCL4 intraperitonealy was injected 1ml/Kg twice a week for 8 weeks 106 allogenic BMMSCs were infused in cell therapy group via tail v...

Journal: :Cancer research 2012
Ayaka M Silverman Rie Nakata Hiroyuki Shimada Richard Sposto Yves A DeClerck

Interleukin-6 (IL-6) is a pleiotropic cytokine with a broad range of physiologic and pathologic functions. Because in cancer, IL-6 contributes to a microenvironment that promotes tumor cell survival, angiogenesis, and inflammation, understanding the mechanism responsible for its production is important. In neuroblastoma, the second most common solid tumor in children, IL-6 is produced not by tu...

2014
Sven Brandau Mark Jakob Kirsten Bruderek Friedrich Bootz Bernd Giebel Stefan Radtke Katharina Mauel Marcus Jäger Stefanie B. Flohé Stephan Lang Roland Jacobs

BACKGROUND Mesenchymal stem cells (MSCs) participate in the regulation of inflammation and innate immunity, for example by responding to pathogen-derived signals and by regulating the function of innate immune cells. MSCs from the bone-marrow and peripheral tissues share common basic cell-biological functions. However, it is unknown whether these MSCs exhibit different responses to microbial ch...

Journal: :Biomaterials 2011
Francesca Colazzo Padmini Sarathchandra Ryszard T Smolenski Adrian H Chester Yuan-Tsan Tseng Jan T Czernuszka Magdi H Yacoub Patricia M Taylor

A key challenge in tissue engineering a heart valve is to reproduce the major tissue structures responsible for native valve function. Here we evaluated human adipose-derived stem cells (ADSCs) as a source of cells for heart valve tissue engineering investigating their ability to synthesize and process collagen and elastin. ADSCs were compared with human bone marrow mesenchymal stem cells (BmMS...

2011
Gang Hu Jun-jun Xu Zhi-hong Deng Jie Feng Yan Jin

Increasing evidence shows that some cells from peripheral blood fibroblast-like mononuclear cells have the capacity to differentiate into mesenchymal lineages. However, the insufficiency of these cells in the circulation challenges the cell isolation and subsequently limits the clinical application of these cells. In the present study, the peripheral blood mononuclear cells (pbMNCs) were isolat...

Journal: :Molecules 2018
Xican Li Ke Li Hong Xie Yulu Xie Yueying Li Xiaojun Zhao Xiaohua Jiang Dongfeng Chen

In this study, a series of di-O-caffeoylquinic acids (di-COQs) were systematically investigated for their antioxidant and cytoprotective effects towards •OH-damaged bone marrow-derived mesenchymal stem cells (bmMSCs). Five di-COQs were measured using a set of antioxidant assays. The results show that adjacent 4,5-Di-O-caffeoylquinic acid (4,5-COQ) and 3,4-di-O-caffeoylquinic acid (3,4-COQ) alwa...

2015
Natasha Fillmore Alda Huqi Jagdip S. Jaswal Jun Mori Roxane Paulin Alois Haromy Arzu Onay-Besikci Lavinia Ionescu Bernard Thébaud Evangelos Michelakis Gary D. Lopaschuk

Successful stem cell therapy requires the optimal proliferation, engraftment, and differentiation of stem cells into the desired cell lineage of tissues. However, stem cell therapy clinical trials to date have had limited success, suggesting that a better understanding of stem cell biology is needed. This includes a better understanding of stem cell energy metabolism because of the importance o...

2015
Yulin An Wei wei Huan Jing Leiguo Ming Shiyu Liu Yan Jin

Cutaneous wounds are among the most common soft tissue injuries. Wounds involving dermis suffer more from outside influence and higher risk of chronic inflammation. Therefore the appearance and function restoration has become an imperative in tissue engineering research. In this study, cell-aggregates constructed with green fluorescent protein-expressing (GFP(+)) rat bone marrow mesenchymal ste...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید