The intraosseous benign notochordal cell tumor (BNCT) is an intravertebral lesion derived from notochordal tissue. The notochord develops in humans during the third week of embryonic life and persists in adults as the nucleus pulposus of the vertebral disks. The most common locations of such tumors are the saccrococcygeal region and the skull base. Most tumors are asymptomatic and small. Magnet...

A boron compound is administered intravenously to the patient, in whom it accumulates preferentially in malignant tumour tissues. The tumour is then irradiated with low-energy neutrons produced by a nuclear reactor. The neutrons are moderated in the patient’s sculp and tissues, so mostly they have energy in tumour. Some of the boron atoms absorb neutrons and then, in a very short time, release ...

In 2001, at the TRIGA reactor of the University of Pavia (Italy), a patient suffering from diffuse liver metastases from an adenocarcinoma of the sigmoid was successfully treated by boron neutron capture therapy (BNCT). The procedure involved boron infusion prior to hepatectomy, irradiation of the explanted liver at the thermal column of the reactor, and subsequent reimplantation. A complete re...

This study was performed to investigate the biological effects of boron neutron capture therapy (BNCT) on the testes and eyes in mice using HANARO Nuclear Reactor, Korea Atomic Energy Research Institute. BNCT relies on the high capacity of 10B in capturing thermal neutrons. Sodium borocaptate (BSH, 75 ppm, iv) and boronophenylalanine (BPA, 750 ppm, ip) have been used as the boron delivery agent...

Herein we present the synthesis and characterization of benzo[b]acridin-12(7H)-ones bearing carboranyl moieties and test their biological effectiveness as boron neutron capture therapy (BNCT) agents in cancer treatment. The cellular uptake of these novel compounds into the U87 human glioblastoma cells was evaluated by boron analysis (ICP-MS) and by fluorescence imaging (confocal microscopy). Th...

introduction electron linear accelerator (linac) can be used for neutron production in boron neutron capture therapy (bnct). bnct is an external radiotherapeutic method for the treatment of some cancers. in this study, varian 2300 c/d linac was simulated as an electron accelerator-based photoneutron source to provide a suitable neutron flux for bnct. materials and methods photoneutron sources w...

Abstract The dose analysis of Boron Neutron Capture Therapy (BNCT) on head cancer using the Particle and Heavy Ion Transport Code System (PHITS) has been carried out. purpose this study was determine rate received irradiation time required for therapy BNCT method. research conducted through a simulation approach. PHITS code used to design an epithermal neutron source derived from accelerator de...

In boron neutron capture therapy (BNCT), drugs should accumulate selectively within a tumor and be quickly cleared from blood normal organs. However, it is usually challenging to achieve the efficient accumulation quick clearance simultaneously. Here we report complex composed of fructose-modified poly(ethylene glycol)-poly(l-lysine) block copolymer p-boronophenylalanine, termed PEG-P[Lys/Lys(f...

The data presented in this article are related to the research article entitled "Synthesis and Characterization of Boron Fenbufen and its F-18 Labeled Homolog for Boron Neutron Capture Therapy of COX-2 Overexpressed Cholangiocarcinoma". The contents of the data article include 1) the set up for performing in vitro binding assay, 2) 1H-, 13C- and 19F-NMR of compounds described in main text, 3) H...