Cholesteatoma of the External Auditory Canal Cholesteatoma of (CEAC) is defined as an accumulation of keratin that produces periosteitis and bone erosion of its walls [1-4] (usually in their lower portions or above) the eardrum and middle ear sometimes not affected [5]. It differs from the keratosis obturans because it produces a circumferential widening of the EAC, chronic Otorrhea and pain, b...

Osteoporosis causes significant health care and economic burden to society, leading to a relentless search for effective preventive agents. Tocotrienol, a member of the vitamin E family, has demonstrated promising potential as an osteoporosis-preventing agent. This review summarizes evidence on the effects of tocotrienol on bone in animal models. Techniques used to examine the effects of tocotr...

Three cases of intracranial dural chondrosarcoma are reported. The radiologic appearance of this slow-growing, extraaxial malignant tumor is different from the more familiar skull-base chondrosarcoma and may mimic an atypical meningioma. Dural chondrosarcoma tends to be less calcified or even to lack matrix calcification; it is associated with bone erosion but not with bone destruction or hyper...

INTRODUCTION Single nucleotide polymorphisms (SNPs) of transforming growth factor β (TGF-β) and IL-6 genes (respectively, 869C/T and -174G/C) have been associated with radiographic severity of bone-erosive damage in patients with rheumatoid arthritis (RA). Musculoskeletal ultrasound (US) is more sensitive than radiography in detecting bone erosion. We analyzed the association between TGF-β 869C...

BACKGROUND Glucocorticoid induced osteoporosis is a common clinical problem. OBJECTIVE To determine the pathophysiology of glucocorticoid induced osteoarthritis at the organ level. METHODS Iliac crest biopsy specimens were obtained from nine patients receiving prednisone treatment for rheumatoid arthritis. Osteocyte viability and histomorphometric indices were assessed. RESULTS Compared w...

A simple bone cyst of the proximal humeral metaphysis was found to cause growth disturbance with shortening and deformity in four patients. All had one pathological fracture. Three of them were treated with cortisone injections; the fourth patient, who presented an erosion of the physis, was treated with saline solution irrigation. Four hypotheses about the aetiology of growth arrest in the evo...

INTRODUCTION Psoriatic arthritis (PsA) is a chronic inflammatory arthritis characterized by bone erosion mediated by osteoclasts (OC). Our previous studies showed an elevated frequency of OC precursors (OCP) in PsA patients. Here, we examined if OC arise from CD16-positive monocytes in PsA. METHODS Peripheral blood mononuclear cells (PBMC) or monocytes were isolated from human peripheral bloo...

The retrospective study was conducted in Nishtar Medical Hospital & Bakhtawar Amin from January 2021 to 2022 evaluate CT findings of bone erosion and the implication surgical treatment patients with AFRS. on a total 140 patients. All underwent sinus examination before start treatment. Experienced neuroradiologist examined characteristics erosion. Data were recorded, including disease locati...

The necropsy of an 84-year-old woman with painful polyarticular gout showed a severe erosion of the L2 vertebral body due to sodium urate deposition. The radiological signs of this tophus had existed for many years; it had caused recurrent pain but no neurological complications. A small tophus and a Schmorl's node on 2 neighbouring thoracic vertebrae permitted the differentiation between verteb...

D a t a e x t r a c t i o n 2 reviewers independently extracted data on sample size, follow-up, patient characteristics, duration of disease, details of the intervention, study quality, and outcomes. For each RCT, the main outcome (bone erosion scores in joints) was converted into the standardized mean difference (difference between the mean change from baseline in erosion scores between the in...