The constitutively active tyrosine kinase BCR-ABL is the underlying cause of chronic myeloid leukemia (CML). Current CML treatments rely on the long-term use of tyrosine kinase inhibitors (TKIs), which target the ATP binding site of BCR-ABL. Over the course of treatment, 20-30% of CML patients develop TKI resistance, which is commonly attributed to point mutations in the drug-binding region. We...

The tropical plant Clitoria ternatea is a member of the Fabaceae family well known for its medicinal values. Heat extraction of C. ternatea revealed that the bioactive fractions contained heat-stable cysteine-rich peptides (CRPs). The CRP family of A1b (Albumin-1 chain b/leginsulins), which is a linear cystine knot CRP, has been shown to present abundantly in the Fabaceae. In contrast, the cycl...

This article offers a comparative analysis of two works world classics: A. Kuprin's short story "The Garnet Bracelet" and S. Zweig's novella Letter Stranger", dedicated to the topic unhappy love. The revealed commonality storyline, presence motive prayer, passion gratitude in it.

The association between human computer interaction methods within traditional design methods is presented in this paper. The engineering degree of industrial design and product development is composed by subjects and an international mobility program that facilitates this relationship. For this reason the role playing model is used with the aim to work with multidisciplinary teams. This paper s...

Developing persuasive interactive system faces the challenge of describing multiple-domain goals to be achieved, along with an context-aware driving of persuasion. We developed ProSPer, a model capable of dealing with this challenges and we implemented two experiments using an Android application and a selfmonitoring bracelet. The preliminary results shows that participants understood and appli...

Plant cyclotides are the largest family of gene-encoded cyclic proteins. They act as host defense molecules to protect plants and are promising candidates as insecticidal and nematocidal agents in agriculture. For this promise to be realized a greater understanding of the post-translational processing of these proteins is needed. Cyclotides are cleaved from precursor proteins with subsequent li...