Acute central nervous system (CNS) injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide, largely attributable to the development of cerebral oedema and elevated intracranial pressure (ICP). Despite this, clinical treatments are limited and new therapies are urgently required to improve patient outcomes and survival....

The radiological finding of a calcified intracranial lesion commonly represents a slow growing benign mass. Brain metastases originating from colorectal cancers are rare, occurring in approximately 2-3% of patients. Therefore the presence of a calcified brain lesion in a patient with a positive oncological history requires a high index of suspicion for brain metastases. Presented herein is a ca...

BACKGROUND Cerebral disorders caused by brain oedema characterize the dialysis disequilibrium syndrome, a complication of rapid haemodialysis. Brain oedema is presumably caused by the 'reverse urea effect', i.e. the significant urea gradient between blood and brain after dialysis, with, as a result, an inflow of water into the brain. To assess the molecular basis of this effect, we examined the...

The aim of this case report is to point out the neurological signs, long term management and MRI lesions suggestive cerebral haemorrhage in a dog with IMHA concurrent thrombocytopenia. A 3.5-year-old intact female Cocker Spaniel was examined for anorexia, weakness, exercise intolerance two collapse episodes. Based on diagnostic procedures primary immune mediated hemolytic anaemia severe thrombo...

OBJECTIVES The relation between complicated early childhood convulsion (ECC) and adult epilepsy is unclear, although a history of complicated ECC is obtainable in half of adults with epilepsy associated with hippocampal sclerosis. It is not known if the ECC is a marker of pre-existing brain damage or is itself harmful to the developing brain. The objective of the study was to assess the extent ...

To cite: Gaete D, LopezRueda A. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204419 DESCRIPTION A 75-year-old man with a history of chronic obstructive pulmonary disease was found in cardiopulmonary arrest. After successful resuscitation the patient was transferred to our institution. On arrival, a non-enhanced brain CTwas performed to assess brain damage, ...

Formation of cerebral oedema caused by vascular leakage is a major problem in various injuries of the CNS, such as stroke, head injury and high-altitude illness. A common feature of all these disorders is the fact that they are associated with tissue hypoxia. Hypoxia has therefore been suggested to be an important pathogenic factor for the induction of vascular leakage in the brain. Vascular en...