Analytical isoelectric focusing in polyacrylamide gel at pH 2.5 to pH 5 was used successfully to detect an acidic protein which can be found in large quantities in the sera of cancer patients but in only small amounts ¡nthe sera of healthy persons. The main peak of this acidic protein when obtained from cancer patients revealed a pi of 3.0, while the pi of that obtained from normal subjects wa...

Optically pure â,â-dimethylated amino acid building blocks with functionalized side chains have been prepared from D-aspartic acid. The dimethylation was accomplished by regioselective dialkylation of 9-phenylfluorenyl (PhFl)-protected aspartate diesters. The bulk of the PhFl protecting group also allowed for a variety of functional group manipulations to be carried out on the side chain withou...

The eVects of combined treatment with cyclophosphamide (CTX) and interferon-â (IFN-â) are described in selected patients with “rapidly transitional” multiple sclerosis. This form of multiple sclerosis is extremely active with very frequent and severe attacks which produce a dramatic increase on the expanded disability status scale (EDSS). Ten patients with rapidly transitional multiple sclerosi...

ti,2f3= 99.0 ± 44.5 mm, t112y = 1213 ± 493 mm, V@ (Va) 4.81 ±2.l2lihens, V@= 58.2 ±50.Slihens,V7 = 598 ±294 liters. Vincnishine, studied only for hhe finsh 4 hn, behaved like a Iwo-compartment system, wihh values of t,,2 a 3.37 ±0.72 min,t,,2 /3 = 155 ±18 mm, v@= 4.53 ±0.49 liters, and V@ = 57.3 ± 21.1 liters. Urine excretiondaha demonstrahed that most drug elimination occurred wihhin ...

This paper presents an approach to classifying amorphous polymer materials. Temperature is classification involves the determination of mechanical and viscoelastic characteristics considered a descriptive variable clarify specific field practical applications polymers. according reference temperature characterizing behaviour The polymers such as methyl poly-methacr...

We describe studies of folate analogue transport in purified epithelial Å“il fractions isolated from mouse small intestine. Fractionation of these cells into immature proliferative and mature absorptive components and two components representative of intermediate stages of maturation was carried out by stepwise, nonenzymatic stripping of the everted organ. In contrast to the proliferative-speci...