Using 1710 Thoroughbred racehorses in Japan, a cohort study was performed to evaluate the influence of genotypes at four single nucleotide polymorphisms (SNPs) on equine chromosome 18 (ECA18), which were associated in a previous genome-wide association study for racing performance with lifetime earnings and performance rank. In males, both g.65809482T>C and g.65868604G>T were related to perform...

OBJECTIVES The aim of this study was to identify and analyse the first integrative and conjugative element (ICE) from Mannheimia haemolytica, the major bacterial component of the bovine respiratory disease (BRD) complex. METHODS The novel ICEMh1 was discovered in the whole-genome sequence of M. haemolytica 42548 by sequence analysis and comparative genomics. Transfer of ICEMh1 was confirmed b...

Chromatin-based DNA damage response (DDR) pathways are fundamental for preventing genome and epigenome instability, which are prevalent in cancer. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) catalyze the addition and removal of acetyl groups on lysine residues, a post-translational modification important for the DDR. Acetylation can alter chromatin structure as well as fu...

Bovine respiratory disease (BRD) complex is a major disease, classically in the indoor calves and feedlot young cattle. The etiopathogenesis of BRD is multifactorial and complex. In this complex etiology an equivalent role plays both the infectious agents as well as the environmental factors which are called also as environmental stressors (inappropriate livestock management like mistakes in an...

Methods to improve accuracy of preclinical detection of bovine respiratory disease (BRD) are needed to reduce the economic impact of this disease, improve animal welfare, and promote more judicious use of antimicrobials in beef cattle. The objectives of this study were to retrospectively characterize time-series deviations in DMI and feeding behavior patterns preceding the display of observed c...

Sir, Bovine respiratory disease (BRD) is one of the economically most important diseases in animal production, with global losses of the feedlot industry due to BRD being estimated to be over US$ 3 billion per year. Antimicrobial agents, particularly macrolides, are commonly used to combat bacteria involved in BRD, such as Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. Aft...

Inherited germline mutations in the tumor suppressor gene BRCA1 predispose individuals to early onset breast and ovarian cancer. BRCA1 together with its structurally related partner BARD1 is required for homologous recombination and DNA double-strand break repair, but how they perform these functions remains elusive. As part of a comprehensive search for DNA repair genes in C. elegans, we ident...

OBJECTIVE To determine the effect of transportation stress on serum concentrations of oxidative stress biomarkers of calves. ANIMALS 105 crossbred beef steer calves (mean [+/-SD] body weight, 207 +/- 21.2 kg). PROCEDURE Calves were assembled at 1 location in Tennessee, and pretransit (day -3) blood samples were collected. Calves were allotted randomly by body weight into 2 groups. Calves we...

This paper describes a study aimed at quantification of expert opinion on risk factors for clinical bovine respiratory disease (BRD) in dairy youngstock in The Netherlands. For this purpose, a panel of 21 experts working in the field of BRD was selected. Total expert consultation consisted of five different rounds and included four rounds that comprised questionnaires held by mail and a 1-day w...

Bovine respiratory disease (BRD) is a complex syndrome caused by several viruses complicated by secondary bacterial infections. The economic consequences of this syndrome are considerable, in terms of loss from death, decreased growth performance, increased medication costs, and labor. There is a wide variety of therapeutic options, most of which involve the use of antibiotics. There is increas...