abstract bachground and aim: mutation analysis of mitochondrial genome and brca genes are helpful in the early diagnosis of familial breast cancers. in this study, we investigated mitochondrial common deletion and brca mutations through multiplex pcr and clinical parameters for the detection of familial breast cancers in archival breast cancer samples. methods: the multiplex pcr was conducted o...

circulating tumor cells (ctcs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. however, the clinical significance of ctcs enumeration and molecular characterization in thepersonalization of breast cancer diagnosis and treatment remains under the debate. a literature search in pubmed, web of ...

conclusions our study revealed that patients with the diagnosis of breast cancer have greater bpe in comparison with control group. the results may be indicative for higher probability of developing breast cancer in patients with higher bpe. therefore, ce-mri could be a useful tool for breast cancer risk assessment. objectives background parenchymal enhancement (bpe) on contrast-enhanced magnet...

background: a soluble form of her-2/neu extracellular domain (sher-2) is reported to be released in the sera of metastatic breast cancer patients. objective: to measure the level of sher-2 in sera of 115 breast cancer patients. methods: serial samples of 27 patients with metastasis, 18 non-metastatic patients, 15 patients in stage 0/i and 14 patients with accompanying benign breast disease were...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...

absract idiopathic granulomatous mastitis is a rare, inflammatory, and benign breast disease characterized by non-caseating granulomata and microabscesses limited to breast lobules. this condition presents as a firm breast mass that is clinically and radiologically indistinguishable from breast cancer, or as multiple or recurrent abscesses, or mastitis in a young non-lactating woman. almost alw...

nodular fasciitis of the breast is a rare benign pathology of soft tissue that is a consequence of fibroblastic hyperplasia within breast. it can mimic breast cancer clinically, radiologically, and histopathologically. a-43 year-old female with a painless mass within upper-lateral quadrant of her left breast complained of rapid and progressive growth during previous few days. no evidence of nip...

Breast cancer is one of the most common cancer in the world. Early detection of cancers cause significantly reduce in morbidity rate and treatment costs. Mammography is a known effective diagnosis method of breast cancer. A way for mammography screening behavior identification is women's awareness evaluation for participating in mammography screening programs. Todays, intelligence systems could...